RHEB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	34% ± 13%	Explore
fibroblast	39 studies	37% ± 14%	Explore
macrophage	30 studies	32% ± 11%	Explore
smooth muscle cell	30 studies	38% ± 15%	Explore
pericyte	28 studies	36% ± 13%	Explore
natural killer cell	23 studies	23% ± 7%	Explore
endothelial cell of lymphatic vessel	20 studies	35% ± 13%	Explore
T cell	19 studies	22% ± 7%	Explore
conventional dendritic cell	19 studies	30% ± 12%	Explore
basal cell	18 studies	44% ± 20%	Explore
epithelial cell	18 studies	47% ± 22%	Explore
connective tissue cell	17 studies	40% ± 15%	Explore
astrocyte	17 studies	34% ± 15%	Explore
monocyte	16 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	16 studies	22% ± 6%	Explore
non-classical monocyte	15 studies	25% ± 11%	Explore
CD4-positive, alpha-beta T cell	15 studies	22% ± 7%	Explore
myofibroblast cell	15 studies	34% ± 11%	Explore
classical monocyte	14 studies	26% ± 9%	Explore
plasmacytoid dendritic cell	14 studies	26% ± 10%	Explore
mast cell	13 studies	22% ± 6%	Explore
B cell	13 studies	20% ± 8%	Explore
capillary endothelial cell	12 studies	27% ± 8%	Explore
regulatory T cell	12 studies	19% ± 3%	Explore
endothelial cell of vascular tree	12 studies	40% ± 12%	Explore
vein endothelial cell	11 studies	30% ± 9%	Explore
gamma-delta T cell	11 studies	25% ± 12%	Explore
microglial cell	11 studies	26% ± 11%	Explore
myeloid cell	11 studies	37% ± 12%	Explore
dendritic cell	11 studies	31% ± 18%	Explore
type I pneumocyte	10 studies	28% ± 12%	Explore
secretory cell	10 studies	46% ± 23%	Explore
endothelial cell of artery	10 studies	31% ± 10%	Explore
club cell	9 studies	29% ± 12%	Explore
mature NK T cell	9 studies	19% ± 3%	Explore
mesothelial cell	9 studies	41% ± 18%	Explore
glutamatergic neuron	9 studies	36% ± 22%	Explore
ciliated cell	9 studies	38% ± 17%	Explore
alveolar macrophage	8 studies	36% ± 13%	Explore
leukocyte	8 studies	32% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	20% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 3%	Explore
abnormal cell	8 studies	42% ± 17%	Explore
plasma cell	8 studies	32% ± 10%	Explore
type II pneumocyte	8 studies	32% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 4%	Explore
mucosal invariant T cell	7 studies	20% ± 3%	Explore
oligodendrocyte precursor cell	7 studies	28% ± 8%	Explore
respiratory goblet cell	6 studies	29% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
platelet	6 studies	24% ± 5%	Explore
mononuclear phagocyte	6 studies	35% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 6%	Explore
epithelial cell of proximal tubule	6 studies	27% ± 5%	Explore
kidney loop of Henle epithelial cell	6 studies	36% ± 10%	Explore
renal alpha-intercalated cell	6 studies	41% ± 4%	Explore
glial cell	6 studies	30% ± 20%	Explore
innate lymphoid cell	6 studies	26% ± 10%	Explore
Mueller cell	6 studies	49% ± 20%	Explore
GABAergic neuron	6 studies	37% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
ionocyte	5 studies	46% ± 13%	Explore
progenitor cell	5 studies	25% ± 7%	Explore
neuron	5 studies	42% ± 16%	Explore
enterocyte	5 studies	18% ± 2%	Explore
transit amplifying cell	5 studies	26% ± 14%	Explore
retinal ganglion cell	5 studies	73% ± 29%	Explore
precursor B cell	5 studies	26% ± 8%	Explore
cardiac muscle cell	5 studies	22% ± 5%	Explore
T follicular helper cell	5 studies	18% ± 2%	Explore
hepatocyte	5 studies	38% ± 27%	Explore
goblet cell	5 studies	33% ± 14%	Explore
hematopoietic precursor cell	4 studies	38% ± 15%	Explore
pancreatic A cell	4 studies	62% ± 10%	Explore
type B pancreatic cell	4 studies	65% ± 16%	Explore
naive B cell	4 studies	19% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	21% ± 2%	Explore
exhausted T cell	4 studies	22% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	38% ± 4%	Explore
hematopoietic stem cell	4 studies	22% ± 6%	Explore
lymphocyte	4 studies	34% ± 10%	Explore
megakaryocyte	4 studies	33% ± 13%	Explore
memory B cell	4 studies	19% ± 2%	Explore
pro-B cell	4 studies	26% ± 2%	Explore
amacrine cell	4 studies	49% ± 19%	Explore
retina horizontal cell	4 studies	41% ± 14%	Explore
adventitial cell	4 studies	30% ± 14%	Explore
adipocyte	4 studies	23% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	44% ± 7%	Explore
T-helper 17 cell	4 studies	24% ± 4%	Explore
interneuron	4 studies	37% ± 20%	Explore
deuterosomal cell	3 studies	35% ± 8%	Explore
duct epithelial cell	3 studies	21% ± 3%	Explore
pancreatic D cell	3 studies	64% ± 16%	Explore
glomerular endothelial cell	3 studies	21% ± 1%	Explore
podocyte	3 studies	53% ± 3%	Explore
neural crest cell	3 studies	48% ± 18%	Explore
IgA plasma cell	3 studies	19% ± 1%	Explore
retinal bipolar neuron	3 studies	32% ± 12%	Explore
OFF-bipolar cell	3 studies	51% ± 35%	Explore
GABAergic amacrine cell	3 studies	26% ± 12%	Explore
glycinergic amacrine cell	3 studies	29% ± 11%	Explore
renal principal cell	3 studies	35% ± 10%	Explore
extravillous trophoblast	3 studies	68% ± 8%	Explore
placental villous trophoblast	3 studies	49% ± 1%	Explore
erythroblast	3 studies	40% ± 29%	Explore
neuroendocrine cell	3 studies	29% ± 7%	Explore
retinal cone cell	3 studies	41% ± 14%	Explore
retinal pigment epithelial cell	3 studies	51% ± 19%	Explore
retinal rod cell	3 studies	25% ± 6%	Explore
serous secreting cell	3 studies	33% ± 10%	Explore
chondrocyte	3 studies	32% ± 15%	Explore
intermediate monocyte	3 studies	33% ± 15%	Explore
granulocyte	3 studies	27% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	59% ± 10%	Explore
muscle cell	3 studies	44% ± 15%	Explore
acinar cell	3 studies	47% ± 19%	Explore
pancreatic ductal cell	3 studies	66% ± 6%	Explore
ependymal cell	3 studies	34% ± 17%	Explore
enteroendocrine cell	3 studies	40% ± 18%	Explore
intestinal crypt stem cell	3 studies	19% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 13%	Explore
melanocyte	3 studies	33% ± 2%	Explore
double negative thymocyte	3 studies	30% ± 17%	Explore
oligodendrocyte	3 studies	23% ± 2%	Explore
myoepithelial cell	3 studies	43% ± 17%	Explore
progenitor cell of mammary luminal epithelium	3 studies	36% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	33% ± 13%	Explore
brain	14 studies	29% ± 15%	Explore
peripheral blood	8 studies	23% ± 8%	Explore
kidney	8 studies	28% ± 8%	Explore
eye	8 studies	37% ± 10%	Explore
intestine	7 studies	29% ± 13%	Explore
uterus	5 studies	34% ± 12%	Explore
liver	5 studies	35% ± 25%	Explore
pancreas	4 studies	62% ± 14%	Explore
placenta	4 studies	43% ± 13%	Explore
breast	4 studies	41% ± 7%	Explore
bone marrow	3 studies	21% ± 6%	Explore
heart	3 studies	21% ± 4%	Explore
lymph node	3 studies	35% ± 12%	Explore
prostate	3 studies	63% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5259.29	1445 / 1445	100%	77.60	183 / 183
ovary	100%	4045.97	180 / 180	100%	145.61	430 / 430
stomach	100%	3586.09	359 / 359	100%	72.38	286 / 286
lung	100%	4677.43	577 / 578	100%	86.43	1155 / 1155
brain	100%	5320.88	2640 / 2642	100%	120.79	704 / 705
breast	100%	5117.00	459 / 459	100%	71.39	1115 / 1118
bladder	100%	5876.62	21 / 21	100%	71.31	502 / 504
thymus	100%	4223.38	653 / 653	100%	72.45	602 / 605
prostate	100%	4350.67	244 / 245	100%	55.85	501 / 502
uterus	100%	5152.66	170 / 170	99%	79.46	456 / 459
skin	100%	3877.91	1807 / 1809	99%	88.05	469 / 472
adrenal gland	100%	5714.67	258 / 258	99%	81.98	228 / 230
kidney	100%	4052.28	89 / 89	99%	54.78	893 / 901
intestine	100%	4794.90	966 / 966	99%	69.09	522 / 527
pancreas	100%	2411.85	328 / 328	99%	60.80	176 / 178
liver	100%	2389.10	226 / 226	98%	46.30	398 / 406
adipose	100%	5422.58	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5322.07	1335 / 1335	0%	0	0 / 0
muscle	100%	5394.44	803 / 803	0%	0	0 / 0
spleen	100%	3146.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.93	45 / 45
ureter	0%	0	0 / 0	100%	27.05	1 / 1
heart	97%	4101.93	836 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	29.57	28 / 29
eye	0%	0	0 / 0	90%	33.01	72 / 80
peripheral blood	58%	925.11	540 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000074	Biological process	regulation of type B pancreatic cell development
GO_0007165	Biological process	signal transduction
GO_0031669	Biological process	cellular response to nutrient levels
GO_0048714	Biological process	positive regulation of oligodendrocyte differentiation
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0048709	Biological process	oligodendrocyte differentiation
GO_0016241	Biological process	regulation of macroautophagy
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0032008	Biological process	positive regulation of TOR signaling
GO_0051726	Biological process	regulation of cell cycle
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0005886	Cellular component	plasma membrane
GO_0005681	Cellular component	spliceosomal complex
GO_0012505	Cellular component	endomembrane system
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0000139	Cellular component	Golgi membrane
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005765	Cellular component	lysosomal membrane
GO_0019003	Molecular function	GDP binding
GO_0019901	Molecular function	protein kinase binding
GO_0000287	Molecular function	magnesium ion binding
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0005525	Molecular function	GTP binding
GO_0030295	Molecular function	protein kinase activator activity
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RHEB
Protein name	Ras homolog, mTORC1 binding Ras homolog enriched in brain GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Synonyms	RHEB2 tcag7.909 hCG_19586
Description	FUNCTION: Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth . In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) . RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes . In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 . Has low intrinsic GTPase activity . .
Accessions	F8WBL3 ENST00000470370.1 ENST00000472642.5 ENST00000478470.5 C9J931 A0A090N900 Q6NZ61 Q15382 C9J469 ENST00000496004.5 ENST00000262187.10

RHEB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review