ABL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0035640Biological processexploration behavior
GO_0010976Biological processpositive regulation of neuron projection development
GO_0007165Biological processsignal transduction
GO_1903905Biological processpositive regulation of establishment of T cell polarity
GO_0007155Biological processcell adhesion
GO_0051353Biological processpositive regulation of oxidoreductase activity
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0010506Biological processregulation of autophagy
GO_0036211Biological processprotein modification process
GO_2000145Biological processregulation of cell motility
GO_0030100Biological processregulation of endocytosis
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_2000406Biological processpositive regulation of T cell migration
GO_0030155Biological processregulation of cell adhesion
GO_0005886Cellular componentplasma membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0003785Molecular functionactin monomer binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0051015Molecular functionactin filament binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0030145Molecular functionmanganese ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameABL2
Protein nameTyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
SynonymsARG
ABLL
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). .

AccessionsP42684
ENST00000367623.8 [P42684-6]
ENST00000504405.5 [P42684-4]
ENST00000507173.5 [P42684-7]
ENST00000502732.6 [P42684-1]
ENST00000344730.8 [P42684-10]
ENST00000512653.5 [P42684-3]
ENST00000511413.5 [P42684-5]