ULK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0048668Biological processcollateral sprouting
GO_0000045Biological processautophagosome assembly
GO_0007165Biological processsignal transduction
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0042594Biological processresponse to starvation
GO_0010508Biological processpositive regulation of autophagy
GO_0048675Biological processaxon extension
GO_0000422Biological processautophagy of mitochondrion
GO_0061709Biological processreticulophagy
GO_0006914Biological processautophagy
GO_0046777Biological processprotein autophosphorylation
GO_0048671Biological processnegative regulation of collateral sprouting
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameULK2
Protein nameSerine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)
Unc-51 like autophagy activating kinase 2
SynonymsKIAA0623
DescriptionFUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. .

AccessionsQ8IYT8
K7EP89
K7EKK9
ENST00000580118.2
K7EIU2
ENST00000575432.1
ENST00000361658.6
ENST00000574732.6
ENST00000395544.9