Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 11 studies | 29% ± 11% | |
glutamatergic neuron | 9 studies | 42% ± 24% | |
microglial cell | 8 studies | 26% ± 8% | |
astrocyte | 8 studies | 31% ± 12% | |
GABAergic neuron | 7 studies | 46% ± 19% | |
interneuron | 6 studies | 45% ± 23% | |
macrophage | 6 studies | 27% ± 4% | |
oligodendrocyte precursor cell | 6 studies | 25% ± 9% | |
neuron | 5 studies | 29% ± 13% | |
endothelial cell | 5 studies | 30% ± 11% | |
ciliated cell | 4 studies | 21% ± 4% | |
GABAergic interneuron | 3 studies | 28% ± 4% | |
granule cell | 3 studies | 21% ± 4% | |
adipocyte | 3 studies | 18% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 12 studies | 35% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2353.53 | 244 / 245 | 100% | 11.53 | 502 / 502 |
brain | 100% | 4265.54 | 2642 / 2642 | 99% | 18.82 | 701 / 705 |
breast | 100% | 2222.93 | 459 / 459 | 99% | 14.56 | 1111 / 1118 |
thymus | 100% | 1808.07 | 652 / 653 | 99% | 8.46 | 597 / 605 |
uterus | 100% | 2747.84 | 170 / 170 | 97% | 9.19 | 445 / 459 |
lung | 99% | 1974.27 | 575 / 578 | 96% | 7.67 | 1114 / 1155 |
kidney | 99% | 1464.03 | 88 / 89 | 96% | 8.92 | 868 / 901 |
skin | 100% | 1883.28 | 1801 / 1809 | 94% | 9.86 | 445 / 472 |
adrenal gland | 99% | 1666.85 | 256 / 258 | 94% | 6.43 | 216 / 230 |
bladder | 100% | 2287.19 | 21 / 21 | 93% | 6.21 | 469 / 504 |
esophagus | 100% | 2276.93 | 1439 / 1445 | 93% | 7.82 | 170 / 183 |
ovary | 100% | 2845.64 | 180 / 180 | 91% | 5.50 | 393 / 430 |
pancreas | 94% | 853.49 | 309 / 328 | 94% | 5.92 | 168 / 178 |
stomach | 99% | 1556.46 | 355 / 359 | 83% | 4.40 | 236 / 286 |
intestine | 98% | 2107.32 | 947 / 966 | 82% | 3.74 | 431 / 527 |
adipose | 100% | 2581.34 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2546.10 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1474.87 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 99% | 1396.05 | 794 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 7.88 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 94% | 8.86 | 75 / 80 |
heart | 91% | 1085.14 | 780 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 72% | 3.67 | 21 / 29 |
liver | 26% | 153.81 | 59 / 226 | 41% | 2.17 | 166 / 406 |
peripheral blood | 30% | 260.11 | 283 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0048668 | Biological process | collateral sprouting |
GO_0000045 | Biological process | autophagosome assembly |
GO_0007165 | Biological process | signal transduction |
GO_0034727 | Biological process | piecemeal microautophagy of the nucleus |
GO_0042594 | Biological process | response to starvation |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0048675 | Biological process | axon extension |
GO_0000422 | Biological process | autophagy of mitochondrion |
GO_0061709 | Biological process | reticulophagy |
GO_0006914 | Biological process | autophagy |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0048671 | Biological process | negative regulation of collateral sprouting |
GO_0034045 | Cellular component | phagophore assembly site membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005776 | Cellular component | autophagosome |
GO_0000407 | Cellular component | phagophore assembly site |
GO_0005737 | Cellular component | cytoplasm |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ULK2 |
Protein name | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) Unc-51 like autophagy activating kinase 2 |
Synonyms | KIAA0623 |
Description | FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. . |
Accessions | Q8IYT8 K7EP89 K7EKK9 ENST00000580118.2 K7EIU2 ENST00000575432.1 ENST00000361658.6 ENST00000574732.6 ENST00000395544.9 |