BEX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0030154Biological processcell differentiation
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005667Cellular componenttranscription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0140678Molecular functionmolecular function inhibitor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameBEX1
Protein nameProtein BEX1 (Brain-expressed X-linked protein 1)
Synonyms
DescriptionFUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). .

AccessionsENST00000372728.4
Q9HBH7