ASB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASB2 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0055007Biological processcardiac muscle cell differentiation
GO_0001947Biological processheart looping
GO_0055013Biological processcardiac muscle cell development
GO_0007165Biological processsignal transduction
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0036336Biological processdendritic cell migration
GO_0071800Biological processpodosome assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0035556Biological processintracellular signal transduction
GO_0035914Biological processskeletal muscle cell differentiation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0030018Cellular componentZ disc
GO_0001725Cellular componentstress fiber
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0097602Molecular functioncullin family protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASB2
Protein nameAnkyrin repeat and SOCS box containing 2 (Ankyrin repeat and SOCS box protein 2)
Ankyrin repeat and SOCS box protein 2 (ASB-2)
Synonyms
DescriptionFUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 . Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation . .; FUNCTION: [Isoform 1]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA . Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity). .; FUNCTION: [Isoform 2]: Targets filamins FLNA and FLNB for proteasomal degradation . This leads to enhanced adhesion of hematopoietic cells to fibronectin . Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells . .

AccessionsENST00000555019.6 [Q96Q27-2]
Q96Q27
G3V3P8
ENST00000625949.1
ENST00000556062.5
ENST00000628500.1
ENST00000626017.2
ENST00000557613.1
ENST00000555507.5
ENST00000555287.1
G3V4B2
G3V2Z2
G3V484
ENST00000315988.8 [Q96Q27-1]
ENST00000629617.2 [Q96Q27-1]
ENST00000626296.2
ENST00000612647.3 [Q96Q27-2]