AKAP5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AKAP5 at tissue level.

III. Associated gene sets

GO_0007194Biological processnegative regulation of adenylate cyclase activity
GO_0007165Biological processsignal transduction
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0010738Biological processregulation of protein kinase A signaling
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_1905665Biological processpositive regulation of calcium ion import across plasma membrane
GO_1905751Biological processpositive regulation of endosome to plasma membrane protein transport
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0043197Cellular componentdendritic spine
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0098837Cellular componentpostsynaptic recycling endosome
GO_0005829Cellular componentcytosol
GO_0008287Cellular componentprotein serine/threonine phosphatase complex
GO_0014069Cellular componentpostsynaptic density
GO_0098944Cellular componentpostsynaptic recycling endosome membrane
GO_0060076Cellular componentexcitatory synapse
GO_0032590Cellular componentdendrite membrane
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0050811Molecular functionGABA receptor binding
GO_0097110Molecular functionscaffold protein binding
GO_0031698Molecular functionbeta-2 adrenergic receptor binding
GO_0035254Molecular functionglutamate receptor binding
GO_0008179Molecular functionadenylate cyclase binding
GO_0005516Molecular functioncalmodulin binding
GO_0051018Molecular functionprotein kinase A binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding
GO_0030346Molecular functionprotein phosphatase 2B binding

IV. Literature review

[source]
Gene nameAKAP5
Protein nameAKAP5 protein
A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)
SynonymsAKAP79
DescriptionFUNCTION: Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors . Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses . .

AccessionsQ6PG46
ENST00000320636.5
ENST00000394718.4
P24588