GNAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0016056Biological processG protein-coupled opsin signaling pathway
GO_0097719Biological processneural tissue regeneration
GO_0050917Biological processsensory perception of umami taste
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0008283Biological processcell population proliferation
GO_0014046Biological processdopamine secretion
GO_0042670Biological processretinal cone cell differentiation
GO_0060221Biological processretinal rod cell differentiation
GO_0051344Biological processnegative regulation of cyclic-nucleotide phosphodiesterase activity
GO_0007165Biological processsignal transduction
GO_0014070Biological processresponse to organic cyclic compound
GO_0120302Biological processbackground adaptation
GO_0042462Biological processeye photoreceptor cell development
GO_0050908Biological processdetection of light stimulus involved in visual perception
GO_0007603Biological processphototransduction, visible light
GO_0022400Biological processregulation of opsin-mediated signaling pathway
GO_0009416Biological processresponse to light stimulus
GO_0071257Biological processcellular response to electrical stimulus
GO_0001580Biological processdetection of chemical stimulus involved in sensory perception of bitter taste
GO_0007632Biological processvisual behavior
GO_0016324Cellular componentapical plasma membrane
GO_0032391Cellular componentphotoreceptor connecting cilium
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0016020Cellular componentmembrane
GO_0001917Cellular componentphotoreceptor inner segment
GO_0043025Cellular componentneuronal cell body
GO_0042622Cellular componentphotoreceptor outer segment membrane
GO_0097381Cellular componentphotoreceptor disc membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0019003Molecular functionGDP binding
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0005525Molecular functionGTP binding
GO_0000035Molecular functionacyl binding
GO_0046872Molecular functionmetal ion binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNAT1
Protein nameGuanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain)
G protein subunit alpha transducin 1
SynonymsGNATR
DescriptionFUNCTION: Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina . Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). .

AccessionsC9JCV8
ENST00000440836.1
ENST00000433068.5
ENST00000232461.8
P11488