MKLN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008360Biological processregulation of cell shape
GO_0030036Biological processactin cytoskeleton organization
GO_0002090Biological processregulation of receptor internalization
GO_0007160Biological processcell-matrix adhesion
GO_0001726Cellular componentruffle
GO_0000151Cellular componentubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0098794Cellular componentpostsynapse
GO_0005737Cellular componentcytoplasm
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMKLN1
Protein nameMuskelin 1
Muskelin
Synonyms
DescriptionFUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 . .

AccessionsC9J7E8
ENST00000446815.5
F8WEY7
C9JWX9
ENST00000416992.6
C9JVL5
ENST00000352689.11 [Q9UL63-1]
ENST00000421797.6
C9JXB0
ENST00000429546.5
Q9UL63
ENST00000458153.5