Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 19 studies | 28% ± 7% | |
| lung | 18 studies | 37% ± 12% | |
| intestine | 8 studies | 34% ± 15% | |
| kidney | 8 studies | 26% ± 8% | |
| placenta | 5 studies | 42% ± 26% | |
| bone marrow | 5 studies | 20% ± 3% | |
| pancreas | 4 studies | 56% ± 23% | |
| brain | 4 studies | 31% ± 16% | |
| liver | 4 studies | 23% ± 4% | |
| uterus | 3 studies | 42% ± 18% | |
| adipose | 3 studies | 32% ± 2% | |
| esophagus | 3 studies | 49% ± 23% | |
| breast | 3 studies | 24% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 100% | 9273.34 | 170 / 170 | 100% | 560.21 | 459 / 459 |
| esophagus | 100% | 20977.84 | 1442 / 1445 | 100% | 524.83 | 183 / 183 |
| skin | 100% | 17247.12 | 1809 / 1809 | 100% | 720.94 | 471 / 472 |
| thymus | 100% | 12494.22 | 652 / 653 | 100% | 377.49 | 602 / 605 |
| stomach | 100% | 8734.09 | 359 / 359 | 99% | 461.50 | 284 / 286 |
| lung | 100% | 27006.47 | 578 / 578 | 99% | 556.71 | 1143 / 1155 |
| intestine | 100% | 14433.13 | 966 / 966 | 99% | 464.49 | 521 / 527 |
| bladder | 100% | 12494.14 | 21 / 21 | 98% | 570.79 | 496 / 504 |
| prostate | 100% | 9620.70 | 245 / 245 | 98% | 346.82 | 494 / 502 |
| breast | 100% | 11409.69 | 459 / 459 | 98% | 397.51 | 1097 / 1118 |
| kidney | 100% | 12146.24 | 89 / 89 | 98% | 425.60 | 883 / 901 |
| ovary | 97% | 6658.92 | 175 / 180 | 99% | 429.68 | 427 / 430 |
| adrenal gland | 98% | 10343.50 | 254 / 258 | 95% | 321.23 | 218 / 230 |
| pancreas | 90% | 4786.01 | 296 / 328 | 99% | 534.15 | 177 / 178 |
| liver | 78% | 4504.10 | 176 / 226 | 98% | 300.05 | 399 / 406 |
| brain | 34% | 1298.64 | 902 / 2642 | 92% | 188.37 | 648 / 705 |
| adipose | 100% | 14559.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 850.00 | 29 / 29 |
| spleen | 100% | 30609.73 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 581.92 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 128.17 | 1 / 1 |
| peripheral blood | 99% | 29952.92 | 924 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 10997.33 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 530.05 | 79 / 80 |
| heart | 96% | 8198.51 | 825 / 861 | 0% | 0 | 0 / 0 |
| muscle | 67% | 2696.82 | 539 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007040 | Biological process | lysosome organization |
| GO_0060266 | Biological process | negative regulation of respiratory burst involved in inflammatory response |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0007042 | Biological process | lysosomal lumen acidification |
| GO_0007041 | Biological process | lysosomal transport |
| GO_0007165 | Biological process | signal transduction |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_1902564 | Biological process | negative regulation of neutrophil activation |
| GO_1903979 | Biological process | negative regulation of microglial cell activation |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0002265 | Biological process | astrocyte activation involved in immune response |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_1905247 | Biological process | positive regulation of aspartic-type peptidase activity |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0050821 | Biological process | protein stabilization |
| GO_1903334 | Biological process | positive regulation of protein folding |
| GO_0048680 | Biological process | positive regulation of axon regeneration |
| GO_1905673 | Biological process | positive regulation of lysosome organization |
| GO_0106016 | Biological process | positive regulation of inflammatory response to wounding |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_1900426 | Biological process | positive regulation of defense response to bacterium |
| GO_0002282 | Biological process | microglial cell activation involved in immune response |
| GO_0035578 | Cellular component | azurophil granule lumen |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005770 | Cellular component | late endosome |
| GO_0005768 | Cellular component | endosome |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | GRN |
| Protein name | Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Granulin precursor |
| Synonyms | |
| Description | FUNCTION: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation . Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes . Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB . In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases . Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity . .; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. .; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. . |
| Accessions | ENST00000585512.5 ENST00000589265.5 ENST00000593167.5 K7EQ05 K7ENI2 ENST00000589536.5 ENST00000587109.5 K7EK92 K7EPL0 K7EQA7 K7EQI0 ENST00000053867.8 [P28799-1] K7EJY4 ENST00000592783.5 ENST00000586782.5 ENST00000586443.1 K7ENN1 ENST00000587518.5 ENST00000587387.5 ENST00000591740.5 K7EMR1 ENST00000588143.5 K7EKL3 P28799 ENST00000586242.1 K7EM89 K7EQK6 K7ERM2 K7ELY1 ENST00000588237.5 |
