RHOC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	53% ± 22%	Explore
fibroblast	35 studies	41% ± 17%	Explore
natural killer cell	33 studies	39% ± 15%	Explore
pericyte	31 studies	52% ± 20%	Explore
smooth muscle cell	25 studies	41% ± 15%	Explore
non-classical monocyte	23 studies	55% ± 21%	Explore
endothelial cell of lymphatic vessel	20 studies	62% ± 16%	Explore
conventional dendritic cell	19 studies	30% ± 15%	Explore
basal cell	19 studies	47% ± 17%	Explore
connective tissue cell	18 studies	40% ± 19%	Explore
CD8-positive, alpha-beta T cell	16 studies	22% ± 7%	Explore
dendritic cell	15 studies	34% ± 15%	Explore
capillary endothelial cell	15 studies	55% ± 12%	Explore
epithelial cell	15 studies	45% ± 17%	Explore
macrophage	14 studies	26% ± 10%	Explore
mature NK T cell	14 studies	30% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	40% ± 14%	Explore
endothelial cell of artery	14 studies	56% ± 18%	Explore
myofibroblast cell	13 studies	42% ± 16%	Explore
endothelial cell of vascular tree	13 studies	59% ± 22%	Explore
T cell	12 studies	24% ± 8%	Explore
vein endothelial cell	12 studies	52% ± 16%	Explore
gamma-delta T cell	12 studies	28% ± 10%	Explore
regulatory T cell	11 studies	21% ± 4%	Explore
secretory cell	10 studies	45% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	36% ± 13%	Explore
goblet cell	8 studies	28% ± 10%	Explore
abnormal cell	7 studies	30% ± 13%	Explore
enterocyte	7 studies	55% ± 17%	Explore
club cell	6 studies	30% ± 10%	Explore
leukocyte	6 studies	20% ± 4%	Explore
epithelial cell of proximal tubule	6 studies	41% ± 8%	Explore
progenitor cell	6 studies	29% ± 10%	Explore
innate lymphoid cell	6 studies	30% ± 6%	Explore
myeloid cell	6 studies	26% ± 10%	Explore
platelet	6 studies	27% ± 8%	Explore
plasmacytoid dendritic cell	6 studies	23% ± 6%	Explore
monocyte	5 studies	30% ± 17%	Explore
kidney loop of Henle epithelial cell	5 studies	20% ± 6%	Explore
astrocyte	5 studies	44% ± 22%	Explore
mucosal invariant T cell	5 studies	25% ± 7%	Explore
ciliated cell	5 studies	38% ± 16%	Explore
glial cell	5 studies	49% ± 24%	Explore
respiratory goblet cell	4 studies	39% ± 25%	Explore
classical monocyte	4 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
glomerular endothelial cell	4 studies	59% ± 11%	Explore
CD4-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
mesothelial cell	4 studies	38% ± 19%	Explore
megakaryocyte	4 studies	44% ± 11%	Explore
adventitial cell	4 studies	35% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	46% ± 19%	Explore
luminal cell of prostate epithelium	4 studies	42% ± 13%	Explore
group 3 innate lymphoid cell	4 studies	36% ± 14%	Explore
duct epithelial cell	3 studies	17% ± 1%	Explore
hillock cell	3 studies	21% ± 5%	Explore
neural crest cell	3 studies	28% ± 4%	Explore
microglial cell	3 studies	30% ± 11%	Explore
extravillous trophoblast	3 studies	50% ± 17%	Explore
lymphocyte	3 studies	43% ± 17%	Explore
intraepithelial lymphocyte	3 studies	38% ± 16%	Explore
Mueller cell	3 studies	58% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
exhausted T cell	3 studies	18% ± 2%	Explore
neuron	3 studies	45% ± 13%	Explore
pancreatic ductal cell	3 studies	67% ± 12%	Explore
oligodendrocyte precursor cell	3 studies	37% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	22% ± 4%	Explore
enteroendocrine cell	3 studies	42% ± 11%	Explore
transit amplifying cell	3 studies	17% ± 2%	Explore
keratinocyte	3 studies	22% ± 5%	Explore
melanocyte	3 studies	29% ± 7%	Explore
T-helper 17 cell	3 studies	28% ± 6%	Explore
mononuclear phagocyte	3 studies	38% ± 2%	Explore
hematopoietic stem cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	32% ± 16%	Explore
intestine	11 studies	32% ± 16%	Explore
peripheral blood	8 studies	21% ± 5%	Explore
kidney	8 studies	30% ± 9%	Explore
uterus	5 studies	38% ± 18%	Explore
prostate	5 studies	36% ± 15%	Explore
pancreas	4 studies	24% ± 8%	Explore
eye	4 studies	22% ± 6%	Explore
placenta	4 studies	40% ± 17%	Explore
breast	4 studies	36% ± 15%	Explore
liver	4 studies	20% ± 5%	Explore
heart	3 studies	25% ± 9%	Explore
skin	3 studies	31% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	9446.59	180 / 180	100%	82.43	430 / 430
uterus	100%	12946.26	170 / 170	100%	122.04	459 / 459
skin	100%	11017.80	1808 / 1809	100%	111.59	472 / 472
thymus	100%	9247.84	652 / 653	100%	115.56	605 / 605
prostate	100%	13582.93	245 / 245	100%	127.81	500 / 502
breast	100%	12770.70	459 / 459	100%	141.61	1113 / 1118
lung	100%	14685.41	577 / 578	100%	92.64	1151 / 1155
intestine	100%	12693.24	966 / 966	99%	115.98	523 / 527
bladder	100%	11334.81	21 / 21	99%	107.70	497 / 504
kidney	100%	15176.53	89 / 89	98%	103.50	879 / 901
esophagus	100%	9714.96	1441 / 1445	98%	59.33	179 / 183
adrenal gland	100%	10103.39	258 / 258	97%	69.06	224 / 230
stomach	98%	6607.24	352 / 359	98%	89.97	281 / 286
liver	96%	4409.44	218 / 226	100%	87.85	404 / 406
brain	91%	5138.63	2397 / 2642	100%	113.62	704 / 705
pancreas	92%	3742.18	302 / 328	98%	154.42	175 / 178
adipose	100%	12997.74	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16524.29	1335 / 1335	0%	0	0 / 0
spleen	100%	13060.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	98.68	45 / 45
ureter	0%	0	0 / 0	100%	96.28	1 / 1
heart	100%	10105.79	860 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	97.54	79 / 80
lymph node	0%	0	0 / 0	93%	38.35	27 / 29
muscle	71%	2178.63	572 / 803	0%	0	0 / 0
peripheral blood	67%	3905.09	625 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043297	Biological process	apical junction assembly
GO_0060193	Biological process	positive regulation of lipase activity
GO_1902766	Biological process	skeletal muscle satellite cell migration
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0007165	Biological process	signal transduction
GO_0000281	Biological process	mitotic cytokinesis
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0030335	Biological process	positive regulation of cell migration
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0007015	Biological process	actin filament organization
GO_0044319	Biological process	wound healing, spreading of cells
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0032420	Cellular component	stereocilium
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0032154	Cellular component	cleavage furrow
GO_0005634	Cellular component	nucleus
GO_0019901	Molecular function	protein kinase binding
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RHOC
Protein name	Ras homolog family member C Rho-related GTP-binding protein RhoC Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Synonyms	ARH9 ARHC
Description	FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. . FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. . FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. . FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. . FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. . FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. . FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. .
Accessions	ENST00000425265.6 ENST00000369636.6 ENST00000534717.5 ENST00000369642.7 ENST00000414971.1 E9PQH6 Q5JR05 E9PLA2 ENST00000436685.6 ENST00000484280.6 ENST00000285735.6 ENST00000484054.3 ENST00000528831.5 Q5JR06 P08134 ENST00000369637.5 Q5JR07 E9PN11 ENST00000369633.6 Q5JR08 ENST00000339083.12 ENST00000468093.5 ENST00000369632.6 ENST00000369638.6

RHOC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review