NAMPT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	44 studies	50% ± 21%	Explore
endothelial cell	42 studies	38% ± 15%	Explore
fibroblast	32 studies	42% ± 19%	Explore
classical monocyte	28 studies	69% ± 19%	Explore
conventional dendritic cell	28 studies	42% ± 16%	Explore
monocyte	27 studies	57% ± 21%	Explore
non-classical monocyte	26 studies	70% ± 18%	Explore
smooth muscle cell	24 studies	38% ± 17%	Explore
dendritic cell	22 studies	47% ± 20%	Explore
pericyte	22 studies	41% ± 22%	Explore
neutrophil	18 studies	85% ± 17%	Explore
basal cell	18 studies	31% ± 10%	Explore
regulatory T cell	18 studies	26% ± 8%	Explore
mast cell	16 studies	34% ± 14%	Explore
endothelial cell of lymphatic vessel	16 studies	31% ± 13%	Explore
epithelial cell	15 studies	38% ± 17%	Explore
myeloid cell	14 studies	53% ± 19%	Explore
endothelial cell of vascular tree	13 studies	45% ± 17%	Explore
vein endothelial cell	12 studies	45% ± 17%	Explore
secretory cell	11 studies	32% ± 12%	Explore
B cell	10 studies	23% ± 7%	Explore
endothelial cell of artery	10 studies	33% ± 11%	Explore
type II pneumocyte	9 studies	37% ± 11%	Explore
microglial cell	9 studies	26% ± 16%	Explore
ciliated cell	9 studies	32% ± 15%	Explore
club cell	9 studies	28% ± 12%	Explore
capillary endothelial cell	9 studies	32% ± 15%	Explore
mesothelial cell	9 studies	49% ± 17%	Explore
adipocyte	9 studies	37% ± 16%	Explore
T cell	8 studies	24% ± 8%	Explore
alveolar macrophage	8 studies	41% ± 6%	Explore
type I pneumocyte	8 studies	29% ± 12%	Explore
leukocyte	8 studies	37% ± 17%	Explore
mononuclear phagocyte	8 studies	57% ± 22%	Explore
connective tissue cell	8 studies	36% ± 17%	Explore
respiratory goblet cell	7 studies	32% ± 12%	Explore
myofibroblast cell	7 studies	33% ± 14%	Explore
astrocyte	7 studies	26% ± 12%	Explore
memory B cell	6 studies	20% ± 2%	Explore
intermediate monocyte	6 studies	66% ± 21%	Explore
natural killer cell	5 studies	25% ± 8%	Explore
naive B cell	5 studies	19% ± 4%	Explore
endothelial cell of sinusoid	5 studies	31% ± 7%	Explore
hepatocyte	5 studies	66% ± 17%	Explore
CD4-positive, alpha-beta T cell	5 studies	24% ± 9%	Explore
abnormal cell	5 studies	35% ± 13%	Explore
adventitial cell	5 studies	50% ± 9%	Explore
cardiac muscle cell	5 studies	22% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 2%	Explore
CD8-positive, alpha-beta T cell	5 studies	21% ± 7%	Explore
plasma cell	4 studies	32% ± 10%	Explore
duct epithelial cell	4 studies	21% ± 4%	Explore
squamous epithelial cell	4 studies	53% ± 20%	Explore
plasmacytoid dendritic cell	4 studies	24% ± 8%	Explore
cholangiocyte	4 studies	51% ± 30%	Explore
retinal pigment epithelial cell	4 studies	44% ± 11%	Explore
inflammatory macrophage	4 studies	50% ± 18%	Explore
T follicular helper cell	4 studies	21% ± 3%	Explore
gamma-delta T cell	4 studies	28% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	55% ± 7%	Explore
mature NK T cell	4 studies	24% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	55% ± 5%	Explore
GABAergic neuron	4 studies	29% ± 8%	Explore
glutamatergic neuron	4 studies	41% ± 4%	Explore
plasmablast	3 studies	25% ± 5%	Explore
monocyte-derived dendritic cell	3 studies	63% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	23% ± 7%	Explore
kidney loop of Henle epithelial cell	3 studies	21% ± 7%	Explore
innate lymphoid cell	3 studies	31% ± 13%	Explore
enterocyte	3 studies	23% ± 7%	Explore
tissue-resident macrophage	3 studies	70% ± 13%	Explore
lymphocyte	3 studies	35% ± 8%	Explore
granulocyte	3 studies	53% ± 23%	Explore
muscle cell	3 studies	43% ± 23%	Explore
mucus secreting cell	3 studies	33% ± 11%	Explore
transit amplifying cell	3 studies	26% ± 9%	Explore
interneuron	3 studies	40% ± 6%	Explore
oligodendrocyte	3 studies	22% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	32% ± 4%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	35% ± 15%	Explore
peripheral blood	15 studies	25% ± 8%	Explore
liver	6 studies	34% ± 9%	Explore
brain	6 studies	34% ± 9%	Explore
uterus	5 studies	38% ± 11%	Explore
prostate	5 studies	39% ± 4%	Explore
breast	5 studies	35% ± 11%	Explore
intestine	4 studies	29% ± 10%	Explore
adipose	4 studies	26% ± 6%	Explore
esophagus	4 studies	30% ± 3%	Explore
kidney	3 studies	28% ± 12%	Explore
heart	3 studies	24% ± 6%	Explore
eye	3 studies	37% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	28072.62	575 / 578	100%	110.49	1151 / 1155
breast	98%	13964.60	448 / 459	96%	41.83	1074 / 1118
prostate	84%	10574.62	207 / 245	97%	50.47	487 / 502
liver	93%	24092.50	211 / 226	87%	47.54	355 / 406
esophagus	80%	13701.08	1149 / 1445	99%	124.90	182 / 183
stomach	80%	9952.29	286 / 359	98%	56.90	280 / 286
bladder	81%	11076.19	17 / 21	95%	55.79	478 / 504
skin	79%	6067.12	1425 / 1809	95%	62.02	447 / 472
intestine	68%	6827.44	660 / 966	96%	52.66	507 / 527
ovary	67%	6770.24	121 / 180	94%	25.24	405 / 430
adrenal gland	92%	9126.57	238 / 258	68%	19.69	157 / 230
thymus	66%	5367.38	428 / 653	87%	23.45	527 / 605
kidney	57%	5291.89	51 / 89	94%	44.15	850 / 901
pancreas	48%	3345.05	157 / 328	97%	50.98	172 / 178
uterus	49%	3869.93	84 / 170	94%	48.86	431 / 459
brain	25%	1563.74	648 / 2642	94%	72.65	663 / 705
peripheral blood	100%	81267.57	929 / 929	0%	0	0 / 0
spleen	99%	12765.38	239 / 241	0%	0	0 / 0
adipose	98%	24219.79	1182 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	44.89	42 / 45
blood vessel	90%	12579.33	1205 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	26.41	24 / 29
muscle	78%	7977.57	629 / 803	0%	0	0 / 0
heart	77%	8959.89	667 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	44%	8.22	35 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0009435	Biological process	NAD biosynthetic process
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0051770	Biological process	positive regulation of nitric-oxide synthase biosynthetic process
GO_0034356	Biological process	NAD biosynthesis via nicotinamide riboside salvage pathway
GO_0032922	Biological process	circadian regulation of gene expression
GO_0007267	Biological process	cell-cell signaling
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0060612	Biological process	adipose tissue development
GO_0016607	Cellular component	nuclear speck
GO_0030054	Cellular component	cell junction
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0047280	Molecular function	nicotinamide phosphoribosyltransferase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	NAMPT
Protein name	Nicotinamide phosphoribosyltransferase Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) Nicotinamide phosphoribosyltransferase (EC 2.4.2.12) Nicotinamide phosphoribosyltransferase (NAmPRTase) (EC 2.4.2.12)
Synonyms	PBEF1 PBEF
Description	FUNCTION: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). .
Accessions	A0A0C4DFS8 ENST00000680864.1 ENST00000681255.1 ENST00000681491.1 ENST00000680708.1 ENST00000681550.1 A0A7P0TAS5 ENST00000491027.6 A0A7P0T973 ENST00000680468.1 ENST00000679873.1 A0A7P0Z466 C9JG65 A0A7P0T9F0 A0A7P0T931 ENST00000680129.1 ENST00000424768 A0A7P0TAZ2 ENST00000681494.1 A0A7P0Z437 ENST00000222553.8 A0A7P0T8L3 ENST00000441045.6 A0A7P0TB17 ENST00000417537.2 A0A7P0T862 A0A7P0T8R4 ENST00000681653.1 C9JF35 ENST00000679951.1 ENST00000681936.1 ENST00000680077.1 A0A7P0Z4N0 ENST00000679643.1 ENST00000681456.1 A0A7P0Z4L4 A0A7P0T9I9 ENST00000681391.1 A0A7P0T8Z3 A0A7P0T941 ENST00000681223.1 ENST00000680786.1 ENST00000680991.1 ENST00000489358.5 A0A7P0TAI8 A0A7P0T8D2 ENST00000680584.1 ENST00000681878.1 A0A7P0TA73 ENST00000424768.2 A0A7P0T895 B7Z8W6 ENST00000680675.1 ENST00000354289.9 ENST00000680823.1 A0A7P0TBB7 ENST00000680152.1 P43490

NAMPT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review