HINT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0007165Biological processsignal transduction
GO_0009154Biological processpurine ribonucleotide catabolic process
GO_0016926Biological processprotein desumoylation
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0006508Biological processproteolysis
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0016929Molecular functiondeSUMOylase activity
GO_0043530Molecular functionadenosine 5'-monophosphoramidase activity
GO_0016787Molecular functionhydrolase activity
GO_0000166Molecular functionnucleotide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHINT1
Protein nameAdenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)
Adenosine 5'-monophosphoramidase HINT1 (Desumoylating isopeptidase HINT1) (Histidine triad nucleotide-binding protein 1)
SynonymsPKCI1
hCG_23479
PRKCNH1
HINT
DescriptionFUNCTION: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 . Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) . Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester . Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro . Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide . In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 . Modulates p53/TP53 levels and p53/TP53-mediated apoptosis . Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex . Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 . Deconjugates SUMO1 from RANGAP1 (By similarity). .

AccessionsENST00000508488.2
D6RE99
ENST00000511475.6
D6RC06
H0YC49
A0A384NPU2
A0A6Q8PGQ8
D6REP8
ENST00000513012.2
ENST00000675100.1
ENST00000675372.1
ENST00000675491.1
ENST00000506908.2
ENST00000304043.10
D6RD60
ENST00000520028.2
ENST00000508495.5
P49773
ENST00000504202.1
ENST00000513345.6