SCUBE3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SCUBE3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCUBE3 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0005615Cellular componentextracellular space
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0070700Molecular functionBMP receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0036122Molecular functionBMP binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCUBE3
Protein nameSignal peptide, CUB and EGF-like domain-containing protein 3
SynonymsCEGF3
DescriptionFUNCTION: Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors . It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. .

AccessionsQ8IX30
ENST00000274938.8 [Q8IX30-1]