PRKACB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	26% ± 5%	Explore
CD8-positive, alpha-beta T cell	19 studies	24% ± 7%	Explore
oligodendrocyte	17 studies	54% ± 18%	Explore
astrocyte	16 studies	38% ± 16%	Explore
T cell	15 studies	21% ± 7%	Explore
oligodendrocyte precursor cell	15 studies	54% ± 18%	Explore
CD4-positive, alpha-beta T cell	15 studies	22% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 5%	Explore
macrophage	14 studies	26% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	27% ± 7%	Explore
gamma-delta T cell	14 studies	27% ± 8%	Explore
glutamatergic neuron	12 studies	70% ± 20%	Explore
mature NK T cell	12 studies	22% ± 5%	Explore
endothelial cell	12 studies	32% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	22% ± 4%	Explore
GABAergic neuron	11 studies	62% ± 22%	Explore
microglial cell	11 studies	32% ± 14%	Explore
regulatory T cell	11 studies	19% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	19% ± 3%	Explore
B cell	10 studies	19% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	25% ± 7%	Explore
neuron	8 studies	47% ± 17%	Explore
mucosal invariant T cell	7 studies	19% ± 2%	Explore
amacrine cell	7 studies	38% ± 19%	Explore
retinal cone cell	7 studies	54% ± 27%	Explore
pericyte	6 studies	25% ± 15%	Explore
interneuron	6 studies	68% ± 22%	Explore
retina horizontal cell	6 studies	40% ± 21%	Explore
Mueller cell	6 studies	26% ± 14%	Explore
hematopoietic stem cell	6 studies	26% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
retinal ganglion cell	5 studies	42% ± 13%	Explore
adipocyte	5 studies	20% ± 3%	Explore
fibroblast	5 studies	20% ± 3%	Explore
smooth muscle cell	5 studies	22% ± 4%	Explore
plasmacytoid dendritic cell	5 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	21% ± 3%	Explore
epithelial cell	4 studies	25% ± 6%	Explore
granule cell	4 studies	53% ± 12%	Explore
retinal bipolar neuron	4 studies	40% ± 18%	Explore
cardiac muscle cell	4 studies	23% ± 2%	Explore
lymphocyte	4 studies	34% ± 11%	Explore
myeloid cell	4 studies	23% ± 4%	Explore
retinal rod cell	4 studies	69% ± 20%	Explore
T follicular helper cell	4 studies	21% ± 2%	Explore
innate lymphoid cell	4 studies	21% ± 6%	Explore
dendritic cell	4 studies	23% ± 5%	Explore
mast cell	4 studies	29% ± 9%	Explore
naive B cell	4 studies	19% ± 4%	Explore
memory B cell	4 studies	18% ± 2%	Explore
hematopoietic precursor cell	3 studies	34% ± 17%	Explore
leukocyte	3 studies	31% ± 12%	Explore
plasmablast	3 studies	21% ± 4%	Explore
GABAergic interneuron	3 studies	64% ± 11%	Explore
progenitor cell	3 studies	29% ± 6%	Explore
precursor B cell	3 studies	26% ± 12%	Explore
GABAergic amacrine cell	3 studies	52% ± 12%	Explore
OFF-bipolar cell	3 studies	46% ± 21%	Explore
ON-bipolar cell	3 studies	57% ± 21%	Explore
glycinergic amacrine cell	3 studies	49% ± 9%	Explore
rod bipolar cell	3 studies	46% ± 18%	Explore
exhausted T cell	3 studies	17% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 8%	Explore
double negative thymocyte	3 studies	30% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	54% ± 21%	Explore
peripheral blood	8 studies	18% ± 2%	Explore
eye	8 studies	37% ± 18%	Explore
adipose	4 studies	19% ± 3%	Explore
bone marrow	3 studies	16% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	14852.21	2642 / 2642	100%	98.74	705 / 705
prostate	99%	2631.04	242 / 245	100%	48.43	500 / 502
bladder	100%	3826.62	21 / 21	84%	20.17	421 / 504
thymus	90%	1709.07	590 / 653	89%	23.78	538 / 605
stomach	100%	3171.38	358 / 359	79%	19.77	226 / 286
breast	89%	1619.03	408 / 459	89%	51.90	999 / 1118
intestine	99%	3839.21	958 / 966	77%	21.84	407 / 527
kidney	80%	1505.83	71 / 89	94%	30.29	851 / 901
adrenal gland	81%	1723.13	208 / 258	89%	62.04	205 / 230
uterus	93%	2386.64	158 / 170	76%	15.95	349 / 459
esophagus	75%	2213.27	1081 / 1445	81%	18.37	148 / 183
lung	67%	1149.05	387 / 578	88%	19.25	1016 / 1155
pancreas	32%	480.23	106 / 328	98%	37.46	174 / 178
ovary	79%	1389.67	143 / 180	45%	5.73	192 / 430
skin	35%	675.65	625 / 1809	87%	36.47	411 / 472
ureter	0%	0	0 / 0	100%	17.54	1 / 1
spleen	100%	2997.36	240 / 241	0%	0	0 / 0
blood vessel	99%	3749.10	1324 / 1335	0%	0	0 / 0
adipose	88%	1603.33	1059 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	15.88	39 / 45
lymph node	0%	0	0 / 0	86%	24.66	25 / 29
liver	23%	322.19	53 / 226	55%	8.56	225 / 406
heart	69%	1343.32	590 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	43%	6.14	34 / 80
peripheral blood	40%	844.07	374 / 929	0%	0	0 / 0
muscle	6%	72.80	46 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070613	Biological process	regulation of protein processing
GO_0007188	Biological process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0003091	Biological process	renal water homeostasis
GO_0007165	Biological process	signal transduction
GO_0045879	Biological process	negative regulation of smoothened signaling pathway
GO_0010737	Biological process	protein kinase A signaling
GO_0034380	Biological process	high-density lipoprotein particle assembly
GO_0001843	Biological process	neural tube closure
GO_0006468	Biological process	protein phosphorylation
GO_1904262	Biological process	negative regulation of TORC1 signaling
GO_0005886	Cellular component	plasma membrane
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0097546	Cellular component	ciliary base
GO_0005952	Cellular component	cAMP-dependent protein kinase complex
GO_0005634	Cellular component	nucleus
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0000287	Molecular function	magnesium ion binding
GO_0004691	Molecular function	cAMP-dependent protein kinase activity
GO_0004679	Molecular function	AMP-activated protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRKACB
Protein name	cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) Protein kinase cAMP-activated catalytic subunit beta cAMP-dependent protein kinase (EC 2.7.11.11)
Synonyms	hCG_23660
Description	FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs . PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux . Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis . Phosphorylates GPKOW which regulates its ability to bind RNA . Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR . .
Accessions	ENST00000370685.7 [P22694-2] ENST00000610457.2 ENST00000446538.5 [P22694-9] B1APG3 ENST00000417530.5 A0A087WVC4 ENST00000370689.6 [P22694-1] B2RB89 B1APG1 ENST00000370684.5 ENST00000370688.7 [P22694-8] ENST00000610703.4 [P22694-3] ENST00000450730.5 B1APG2 P22694 ENST00000614872.4 [P22694-6] ENST00000436133.6 [P22694-7] B1APF7 ENST00000394839.6 [P22694-10] B1APG0 ENST00000436133.5 ENST00000432111.5 ENST00000370680.5 B1APF9 ENST00000413538.5 B1APF8

PRKACB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review