IRS4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IRS4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IRS4 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008286Biological processinsulin receptor signaling pathway
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005158Molecular functioninsulin receptor binding
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRS4
Protein nameInsulin receptor substrate 4
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Synonyms
DescriptionFUNCTION: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. .

AccessionsENST00000372129.4
A0A804CF45
O14654
ENST00000564206.2