TTBK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007224Biological processsmoothened signaling pathway
GO_0007165Biological processsignal transduction
GO_1904527Biological processnegative regulation of microtubule binding
GO_0021935Biological processcerebellar granule cell precursor tangential migration
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_1902817Biological processnegative regulation of protein localization to microtubule
GO_0030334Biological processregulation of cell migration
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0021549Biological processcerebellum development
GO_0021681Biological processcerebellar granular layer development
GO_0005615Cellular componentextracellular space
GO_0005814Cellular componentcentriole
GO_0005829Cellular componentcytosol
GO_0035869Cellular componentciliary transition zone
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0005634Cellular componentnucleus
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameTTBK2
Protein nameTau-tubulin kinase 2 (EC 2.7.11.1)
Tau tubulin kinase 2
SynonymsKIAA0847
DescriptionFUNCTION: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro . Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis . .

AccessionsENST00000566931.1
H3BMY7
A0A0B4J292
ENST00000562880.5
ENST00000267890.11 [Q6IQ55-1]
H3BQ25
ENST00000564431.5
ENST00000567274.5
H3BTY5
ENST00000567840.5 [Q6IQ55-3]
Q6IQ55