Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 31% ± 15% | |
astrocyte | 12 studies | 37% ± 18% | |
oligodendrocyte | 11 studies | 34% ± 13% | |
ciliated cell | 10 studies | 27% ± 12% | |
GABAergic neuron | 10 studies | 49% ± 26% | |
glutamatergic neuron | 10 studies | 53% ± 25% | |
microglial cell | 10 studies | 30% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 37% ± 18% | |
macrophage | 8 studies | 33% ± 11% | |
retinal ganglion cell | 7 studies | 40% ± 18% | |
smooth muscle cell | 7 studies | 19% ± 3% | |
neuron | 6 studies | 36% ± 13% | |
retina horizontal cell | 6 studies | 27% ± 12% | |
fibroblast | 6 studies | 24% ± 10% | |
interneuron | 5 studies | 61% ± 24% | |
amacrine cell | 5 studies | 32% ± 15% | |
retinal cone cell | 5 studies | 26% ± 11% | |
cardiac muscle cell | 5 studies | 29% ± 7% | |
dendritic cell | 5 studies | 17% ± 3% | |
granule cell | 4 studies | 27% ± 2% | |
retinal rod cell | 4 studies | 35% ± 7% | |
endothelial cell of lymphatic vessel | 4 studies | 25% ± 6% | |
epithelial cell | 3 studies | 33% ± 10% | |
GABAergic amacrine cell | 3 studies | 30% ± 11% | |
Mueller cell | 3 studies | 25% ± 8% | |
OFF-bipolar cell | 3 studies | 25% ± 5% | |
ON-bipolar cell | 3 studies | 27% ± 8% | |
glycinergic amacrine cell | 3 studies | 30% ± 3% | |
alveolar macrophage | 3 studies | 21% ± 4% | |
monocyte | 3 studies | 23% ± 4% | |
pericyte | 3 studies | 22% ± 7% | |
lymphocyte | 3 studies | 22% ± 5% | |
adipocyte | 3 studies | 20% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2434.58 | 2637 / 2642 | 100% | 7.28 | 703 / 705 |
adrenal gland | 100% | 1357.52 | 258 / 258 | 98% | 6.46 | 225 / 230 |
esophagus | 99% | 1600.19 | 1429 / 1445 | 98% | 4.78 | 180 / 183 |
prostate | 100% | 1746.31 | 245 / 245 | 96% | 3.76 | 482 / 502 |
kidney | 100% | 895.48 | 89 / 89 | 96% | 3.87 | 864 / 901 |
breast | 100% | 1616.80 | 459 / 459 | 95% | 3.66 | 1065 / 1118 |
thymus | 100% | 1392.13 | 651 / 653 | 96% | 3.04 | 578 / 605 |
lung | 100% | 1649.92 | 578 / 578 | 95% | 3.27 | 1098 / 1155 |
uterus | 100% | 2261.34 | 170 / 170 | 93% | 2.77 | 426 / 459 |
skin | 99% | 1165.06 | 1796 / 1809 | 93% | 3.82 | 438 / 472 |
bladder | 100% | 1859.90 | 21 / 21 | 81% | 2.07 | 409 / 504 |
stomach | 91% | 977.11 | 328 / 359 | 84% | 2.29 | 240 / 286 |
ovary | 100% | 1991.07 | 180 / 180 | 73% | 1.39 | 313 / 430 |
pancreas | 77% | 418.57 | 252 / 328 | 94% | 2.79 | 168 / 178 |
intestine | 100% | 1800.77 | 963 / 966 | 70% | 1.55 | 368 / 527 |
liver | 90% | 505.89 | 203 / 226 | 50% | 0.91 | 205 / 406 |
blood vessel | 100% | 2666.00 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2174.76 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1225.24 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.03 | 1 / 1 |
adipose | 100% | 1731.68 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 1636.08 | 836 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 3.04 | 41 / 45 |
eye | 0% | 0 | 0 / 0 | 65% | 1.57 | 52 / 80 |
lymph node | 0% | 0 | 0 / 0 | 62% | 1.57 | 18 / 29 |
peripheral blood | 51% | 477.60 | 477 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060271 | Biological process | cilium assembly |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0007224 | Biological process | smoothened signaling pathway |
GO_0007165 | Biological process | signal transduction |
GO_1904527 | Biological process | negative regulation of microtubule binding |
GO_0021935 | Biological process | cerebellar granule cell precursor tangential migration |
GO_0007026 | Biological process | negative regulation of microtubule depolymerization |
GO_1902817 | Biological process | negative regulation of protein localization to microtubule |
GO_0030334 | Biological process | regulation of cell migration |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0021549 | Biological process | cerebellum development |
GO_0021681 | Biological process | cerebellar granular layer development |
GO_0005615 | Cellular component | extracellular space |
GO_0005814 | Cellular component | centriole |
GO_0005829 | Cellular component | cytosol |
GO_0035869 | Cellular component | ciliary transition zone |
GO_0005737 | Cellular component | cytoplasm |
GO_0036064 | Cellular component | ciliary basal body |
GO_0005634 | Cellular component | nucleus |
GO_0051010 | Molecular function | microtubule plus-end binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0050321 | Molecular function | tau-protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0048156 | Molecular function | tau protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0019894 | Molecular function | kinesin binding |
Gene name | TTBK2 |
Protein name | Tau-tubulin kinase 2 (EC 2.7.11.1) Tau tubulin kinase 2 |
Synonyms | KIAA0847 |
Description | FUNCTION: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro . Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis . . |
Accessions | ENST00000566931.1 H3BMY7 A0A0B4J292 ENST00000562880.5 ENST00000267890.11 [Q6IQ55-1] H3BQ25 ENST00000564431.5 ENST00000567274.5 H3BTY5 ENST00000567840.5 [Q6IQ55-3] Q6IQ55 |