TP53BP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0045786Biological processnegative regulation of cell cycle
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0030054Cellular componentcell junction
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051059Molecular functionNF-kappaB binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0002039Molecular functionp53 binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameTP53BP2
Protein nameApoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
TP53BP2 protein
Tumor protein p53 binding protein 2
SynonymsASPP2
BBP
DescriptionFUNCTION: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 . Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. .

AccessionsH0Y847
ENST00000483398.5
ENST00000391878.6 [Q13625-2]
Q13625
H7C5L8
Q05BL1
ENST00000343537.12 [Q13625-3]
ENST00000494100.1