ARHGAP17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007015Biological processactin filament organization
GO_0017156Biological processcalcium-ion regulated exocytosis
GO_0035020Biological processregulation of Rac protein signal transduction
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0005622Cellular componentintracellular anatomical structure
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameARHGAP17
Protein nameRho GTPase activating protein 17
ARHGAP17
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
SynonymsMSTP066
MSTP110
RICH1
DescriptionFUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. .

AccessionsI3L4Y5
I3L3P1
ENST00000455311.6
ENST00000303665.9 [Q68EM7-2]
I3L1S9
A0A2X0SF71
I3L4P6
ENST00000573625.5
ENST00000573765.1
C9IZD3
ENST00000673196.1 [Q68EM7-2]
ENST00000571843.1
Q68EM7
ENST00000673560.1 [Q68EM7-1]
I3L4P0
ENST00000571480.5
ENST00000289968.11 [Q68EM7-1]
ENST00000571406.1
I3L460
ENST00000573449.5