Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 21 studies | 26% ± 8% | |
endothelial cell | 17 studies | 30% ± 11% | |
naive B cell | 13 studies | 24% ± 6% | |
memory B cell | 11 studies | 24% ± 5% | |
pericyte | 10 studies | 30% ± 13% | |
macrophage | 9 studies | 32% ± 7% | |
plasmacytoid dendritic cell | 9 studies | 32% ± 8% | |
endothelial cell of lymphatic vessel | 9 studies | 34% ± 16% | |
smooth muscle cell | 8 studies | 30% ± 11% | |
microglial cell | 7 studies | 35% ± 13% | |
epithelial cell | 7 studies | 32% ± 21% | |
oligodendrocyte | 7 studies | 34% ± 9% | |
myeloid cell | 6 studies | 25% ± 11% | |
dendritic cell | 6 studies | 24% ± 8% | |
fibroblast | 6 studies | 26% ± 5% | |
interneuron | 5 studies | 32% ± 20% | |
oligodendrocyte precursor cell | 5 studies | 30% ± 13% | |
astrocyte | 5 studies | 30% ± 11% | |
non-classical monocyte | 4 studies | 21% ± 6% | |
neuron | 4 studies | 36% ± 15% | |
precursor B cell | 4 studies | 30% ± 12% | |
immature B cell | 4 studies | 33% ± 10% | |
cardiac muscle cell | 4 studies | 22% ± 4% | |
abnormal cell | 4 studies | 25% ± 9% | |
monocyte | 4 studies | 24% ± 6% | |
granule cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 31% ± 11% | |
lymphocyte | 3 studies | 22% ± 6% | |
goblet cell | 3 studies | 27% ± 14% | |
mesothelial cell | 3 studies | 29% ± 8% | |
glutamatergic neuron | 3 studies | 39% ± 15% | |
GABAergic neuron | 3 studies | 38% ± 15% | |
endothelial cell of artery | 3 studies | 26% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 4941.19 | 258 / 258 | 100% | 18.58 | 230 / 230 |
esophagus | 100% | 3696.09 | 1445 / 1445 | 100% | 22.17 | 183 / 183 |
intestine | 100% | 4577.78 | 966 / 966 | 100% | 20.72 | 527 / 527 |
prostate | 100% | 3550.33 | 245 / 245 | 100% | 13.77 | 502 / 502 |
skin | 100% | 4577.23 | 1809 / 1809 | 100% | 26.16 | 472 / 472 |
stomach | 100% | 3015.42 | 359 / 359 | 100% | 20.87 | 286 / 286 |
lung | 100% | 5011.65 | 578 / 578 | 100% | 16.24 | 1154 / 1155 |
kidney | 100% | 2892.40 | 89 / 89 | 100% | 18.67 | 900 / 901 |
thymus | 100% | 4353.31 | 652 / 653 | 100% | 19.97 | 605 / 605 |
breast | 100% | 5656.12 | 459 / 459 | 100% | 21.79 | 1116 / 1118 |
bladder | 100% | 3408.33 | 21 / 21 | 100% | 16.45 | 503 / 504 |
uterus | 100% | 4768.26 | 170 / 170 | 100% | 16.34 | 458 / 459 |
ovary | 100% | 3682.03 | 180 / 180 | 100% | 16.11 | 429 / 430 |
pancreas | 100% | 1754.27 | 327 / 328 | 100% | 18.06 | 178 / 178 |
liver | 99% | 1644.33 | 224 / 226 | 98% | 9.53 | 398 / 406 |
brain | 95% | 1518.77 | 2508 / 2642 | 100% | 16.01 | 705 / 705 |
adipose | 100% | 6614.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5116.58 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 17.09 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 55.28 | 29 / 29 |
muscle | 100% | 2948.27 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 9302.60 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.76 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.51 | 1 / 1 |
heart | 100% | 3116.68 | 860 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 87% | 3895.99 | 806 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0007015 | Biological process | actin filament organization |
GO_0017156 | Biological process | calcium-ion regulated exocytosis |
GO_0035020 | Biological process | regulation of Rac protein signal transduction |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0005622 | Cellular component | intracellular anatomical structure |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005923 | Cellular component | bicellular tight junction |
GO_0005515 | Molecular function | protein binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | ARHGAP17 |
Protein name | Rho GTPase activating protein 17 ARHGAP17 Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) |
Synonyms | MSTP066 MSTP110 RICH1 |
Description | FUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. . |
Accessions | I3L4Y5 I3L3P1 ENST00000455311.6 ENST00000303665.9 [Q68EM7-2] I3L1S9 A0A2X0SF71 I3L4P6 ENST00000573625.5 ENST00000573765.1 C9IZD3 ENST00000673196.1 [Q68EM7-2] ENST00000571843.1 Q68EM7 ENST00000673560.1 [Q68EM7-1] I3L4P0 ENST00000571480.5 ENST00000289968.11 [Q68EM7-1] ENST00000571406.1 I3L460 ENST00000573449.5 |