INPP4B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	28 studies	38% ± 18%	Explore
smooth muscle cell	19 studies	38% ± 19%	Explore
CD4-positive, alpha-beta T cell	19 studies	34% ± 14%	Explore
T cell	15 studies	29% ± 14%	Explore
astrocyte	15 studies	36% ± 20%	Explore
regulatory T cell	14 studies	25% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	34% ± 15%	Explore
GABAergic neuron	11 studies	50% ± 27%	Explore
glutamatergic neuron	10 studies	54% ± 17%	Explore
CD8-positive, alpha-beta T cell	10 studies	27% ± 11%	Explore
endothelial cell	9 studies	41% ± 18%	Explore
fibroblast	9 studies	33% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	27% ± 7%	Explore
mucosal invariant T cell	8 studies	24% ± 11%	Explore
oligodendrocyte precursor cell	8 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 14%	Explore
interneuron	6 studies	58% ± 30%	Explore
cardiac muscle cell	6 studies	55% ± 24%	Explore
T follicular helper cell	6 studies	32% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	36% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
epithelial cell	5 studies	33% ± 20%	Explore
club cell	5 studies	28% ± 16%	Explore
microglial cell	4 studies	39% ± 22%	Explore
lymphocyte	4 studies	47% ± 18%	Explore
mature NK T cell	4 studies	19% ± 5%	Explore
muscle cell	4 studies	32% ± 8%	Explore
oligodendrocyte	4 studies	35% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 5%	Explore
hepatic stellate cell	3 studies	30% ± 12%	Explore
neuron	3 studies	33% ± 7%	Explore
GABAergic interneuron	3 studies	63% ± 8%	Explore
macrophage	3 studies	26% ± 9%	Explore
ciliated cell	3 studies	24% ± 2%	Explore
GABAergic amacrine cell	3 studies	29% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	30% ± 6%	Explore
retinal pigment epithelial cell	3 studies	34% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	34% ± 3%	Explore
respiratory goblet cell	3 studies	49% ± 12%	Explore
melanocyte	3 studies	47% ± 22%	Explore
basal cell	3 studies	24% ± 5%	Explore
leukocyte	3 studies	46% ± 22%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	34% ± 21%	Explore
peripheral blood	4 studies	16% ± 1%	Explore
lung	4 studies	16% ± 1%	Explore
heart	4 studies	37% ± 10%	Explore
kidney	4 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	98%	1303.28	1771 / 1809	97%	21.44	458 / 472
breast	99%	3238.40	456 / 459	90%	19.54	1002 / 1118
prostate	100%	1285.60	244 / 245	89%	7.67	448 / 502
intestine	100%	1339.68	964 / 966	89%	5.98	468 / 527
bladder	100%	1362.95	21 / 21	88%	8.35	441 / 504
esophagus	99%	1047.04	1426 / 1445	87%	7.82	159 / 183
lung	100%	1821.74	577 / 578	78%	5.88	897 / 1155
kidney	98%	808.19	87 / 89	77%	7.87	697 / 901
uterus	100%	1860.31	170 / 170	72%	5.71	330 / 459
stomach	81%	1069.45	292 / 359	86%	6.05	245 / 286
thymus	99%	1341.80	647 / 653	63%	2.33	383 / 605
pancreas	63%	319.21	207 / 328	96%	14.70	170 / 178
adrenal gland	90%	657.54	232 / 258	47%	2.03	107 / 230
brain	83%	586.65	2187 / 2642	50%	1.69	356 / 705
ovary	95%	995.13	171 / 180	27%	1.03	118 / 430
adipose	100%	2786.28	1204 / 1204	0%	0	0 / 0
spleen	100%	904.20	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	14.83	1 / 1
blood vessel	100%	2583.97	1334 / 1335	0%	0	0 / 0
muscle	99%	1559.10	795 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	91%	13.99	73 / 80
heart	87%	1015.13	753 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	58%	3.21	26 / 45
lymph node	0%	0	0 / 0	48%	2.79	14 / 29
peripheral blood	35%	264.23	329 / 929	0%	0	0 / 0
liver	4%	15.66	8 / 226	10%	0.64	42 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0036092	Biological process	phosphatidylinositol-3-phosphate biosynthetic process
GO_0046856	Biological process	phosphatidylinositol dephosphorylation
GO_0006661	Biological process	phosphatidylinositol biosynthetic process
GO_0043647	Biological process	inositol phosphate metabolic process
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0017161	Molecular function	inositol-1,3,4-trisphosphate 4-phosphatase activity
GO_0005515	Molecular function	protein binding
GO_0016316	Molecular function	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO_0052828	Molecular function	inositol-3,4-bisphosphate 4-phosphatase activity

IV. Literature review

[source]

Gene name	INPP4B
Protein name	Inositol polyphosphate-4-phosphatase type II B Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) INPP4B protein (Inositol polyphosphate-4-phosphatase type II B) phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66)
Synonyms
Description	FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate . Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles . The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival . .
Accessions	ENST00000513000.5 [O15327-1] E9PG59 ENST00000506000.5 A0A0D9SF83 D6RDJ7 D6R9J5 A0A8I5KPN5 H0Y9Q3 D6RJC3 ENST00000509777.5 ENST00000514525.1 E9PCZ3 ENST00000690114.1 ENST00000506217.5 [O15327-2] ENST00000506297.5 E7EQN9 ENST00000692370.1 D6RE59 ENST00000503927.5 E9PHC0 H0YA10 ENST00000510812.5 Q9BS68 ENST00000506788.5 ENST00000508116.5 [O15327-1] ENST00000511838.6 O15327 ENST00000507861.5 ENST00000512630.5 ENST00000262992.9 [O15327-1] A0A8I5KVN1 ENST00000630044.3 ENST00000507462.5

INPP4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review