PRKG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019934Biological processcGMP-mediated signaling
GO_0014050Biological processnegative regulation of glutamate secretion
GO_0048668Biological processcollateral sprouting
GO_0061049Biological processcell growth involved in cardiac muscle cell development
GO_0010920Biological processnegative regulation of inositol phosphate biosynthetic process
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_2000224Biological processregulation of testosterone biosynthetic process
GO_0030900Biological processforebrain development
GO_0007165Biological processsignal transduction
GO_0010737Biological processprotein kinase A signaling
GO_0001764Biological processneuron migration
GO_0060087Biological processrelaxation of vascular associated smooth muscle
GO_0090331Biological processnegative regulation of platelet aggregation
GO_0030036Biological processactin cytoskeleton organization
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0043087Biological processregulation of GTPase activity
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0021549Biological processcerebellum development
GO_1904753Biological processnegative regulation of vascular associated smooth muscle cell migration
GO_0006468Biological processprotein phosphorylation
GO_0016358Biological processdendrite development
GO_0007286Biological processspermatid development
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0042383Cellular componentsarcolemma
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004692Molecular functioncGMP-dependent protein kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0048273Molecular functionmitogen-activated protein kinase p38 binding
GO_0030553Molecular functioncGMP binding
GO_0005246Molecular functioncalcium channel regulator activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKG1
Protein nameProtein kinase cGMP-dependent 1
cGMP-dependent protein kinase (EC 2.7.11.12)
cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)
SynonymsPRKGR1A
PRKG1B
PRKGR1B
DescriptionFUNCTION: Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. .

AccessionsA0A2R8YH74
A0A2R8Y507
B1ALS0
ENST00000373976.9
Q13976
ENST00000645324.1
ENST00000643704.1
ENST00000672084.1
A0A2R8YE50
ENST00000401604.8 [Q13976-1]
ENST00000373980.11 [Q13976-2]
ENST00000643582.1
A0A5F9ZGW0