PDE11A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PDE11A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDE11A at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0019933Biological processcAMP-mediated signaling
GO_0043951Biological processnegative regulation of cAMP-mediated signaling
GO_0010754Biological processnegative regulation of cGMP-mediated signaling
GO_0005575Cellular componentcellular_component
GO_0005829Cellular componentcytosol
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0004114Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0030553Molecular functioncGMP binding
GO_0004112Molecular functioncyclic-nucleotide phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding
GO_0004118Molecular functioncGMP-stimulated cyclic-nucleotide phosphodiesterase activity

IV. Literature review

[source]
Gene namePDE11A
Protein namePhosphodiesterase 11A
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)
Phosphodiesterase (EC 3.1.4.-)
Uncharacterized protein PDE11A
Synonyms
DescriptionFUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP . Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively . .

AccessionsENST00000433879.1
H0Y6P9
E9LCZ2
ENST00000409504.5 [Q9HCR9-3]
E9LCZ3
Q9HCR9
ENST00000358450.8 [Q9HCR9-2]
H7C4D0
ENST00000436700.5
Q53S13
ENST00000389683.7 [Q9HCR9-4]
ENST00000286063.11 [Q9HCR9-1]
F8WDQ4
Q53S07
ENST00000427127.1