CNGB3 | OmnibusX

Name	Number of supported studies	Average coverage
retinal cone cell	8 studies	67% ± 21%	Explore
retinal pigment epithelial cell	4 studies	46% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CNGB3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	94%	28.03	169 / 180	8%	0.15	33 / 430
bladder	86%	4.62	18 / 21	15%	0.25	74 / 504
uterus	92%	23.32	157 / 170	6%	0.11	29 / 459
esophagus	72%	4.43	1041 / 1445	12%	0.20	22 / 183
intestine	76%	7.57	736 / 966	3%	0.04	14 / 527
thymus	76%	3.97	499 / 653	0%	0.01	2 / 605
heart	75%	5.34	648 / 861	0%	0	0 / 0
lung	62%	2.84	358 / 578	12%	0.23	143 / 1155
breast	71%	6.12	328 / 459	3%	0.06	30 / 1118
brain	72%	8.95	1910 / 2642	0%	0.00	2 / 705
skin	70%	3.56	1275 / 1809	0%	0.01	2 / 472
adipose	68%	5.90	821 / 1204	0%	0	0 / 0
pancreas	66%	3.63	216 / 328	2%	0.04	3 / 178
blood vessel	66%	3.20	886 / 1335	0%	0	0 / 0
prostate	62%	2.91	152 / 245	1%	0.04	5 / 502
kidney	60%	5.82	53 / 89	3%	0.07	24 / 901
stomach	59%	3.01	212 / 359	3%	0.06	8 / 286
muscle	59%	2.60	477 / 803	0%	0	0 / 0
spleen	44%	1.56	107 / 241	0%	0	0 / 0
adrenal gland	44%	1.68	114 / 258	0%	0	0 / 230
liver	33%	1.04	75 / 226	1%	0.01	5 / 406
peripheral blood	25%	1.24	229 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.16	2 / 29
eye	0%	0	0 / 0	3%	0.11	2 / 80
tonsil	0%	0	0 / 0	2%	0.04	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0006812	Biological process	monoatomic cation transport
GO_0007601	Biological process	visual perception
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_1902495	Cellular component	transmembrane transporter complex
GO_0017071	Cellular component	intracellular cyclic nucleotide activated cation channel complex
GO_0005886	Cellular component	plasma membrane
GO_0001750	Cellular component	photoreceptor outer segment
GO_0044877	Molecular function	protein-containing complex binding
GO_0005222	Molecular function	intracellularly cAMP-activated cation channel activity
GO_0005223	Molecular function	intracellularly cGMP-activated cation channel activity
GO_0030553	Molecular function	cGMP binding

Gene name	CNGB3
Protein name	Cyclic nucleotide gated channel beta 3 Cyclic nucleotide gated channel subunit beta 3 Cyclic nucleotide-gated cation channel beta-3 (Cone photoreceptor cGMP-gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-3) (CNG channel beta-3) Cyclic nucleotide-gated cation channel beta-3
Synonyms
Description	FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. .
Accessions	Q9NQW8 ENST00000681746.1 H0YAZ4 ENST00000517327.5 Q0QD47 B9EK43 A0A1Y0AYH4 A0A5J6DSN8 A0A1Y0AYH9 ENST00000320005.6 [Q9NQW8-1]

CNGB3 report