GAB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0043306Biological processpositive regulation of mast cell degranulation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0030316Biological processosteoclast differentiation
GO_0045121Cellular componentmembrane raft
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding
GO_0005068Molecular functiontransmembrane receptor protein tyrosine kinase adaptor activity

IV. Literature review

[source]
Gene nameGAB2
Protein nameGRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
GRB2 associated binding protein 2
SynonymsKIAA0571
DescriptionFUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. .

AccessionsENST00000530915.1
ENST00000340149.6 [Q9UQC2-2]
ENST00000361507.5 [Q9UQC2-1]
ENST00000528886.5
E9PJE2
E9PJ26
Q9UQC2