Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 16 studies | 33% ± 16% | |
macrophage | 15 studies | 47% ± 24% | |
oligodendrocyte | 15 studies | 60% ± 17% | |
endothelial cell | 15 studies | 30% ± 11% | |
microglial cell | 14 studies | 62% ± 16% | |
oligodendrocyte precursor cell | 13 studies | 38% ± 17% | |
fibroblast | 12 studies | 33% ± 10% | |
GABAergic neuron | 10 studies | 46% ± 21% | |
glutamatergic neuron | 10 studies | 40% ± 24% | |
myeloid cell | 9 studies | 41% ± 19% | |
adipocyte | 9 studies | 47% ± 10% | |
neuron | 7 studies | 40% ± 21% | |
endothelial cell of lymphatic vessel | 7 studies | 34% ± 10% | |
pericyte | 7 studies | 25% ± 9% | |
classical monocyte | 6 studies | 20% ± 4% | |
interneuron | 6 studies | 43% ± 21% | |
dendritic cell | 6 studies | 41% ± 10% | |
type II pneumocyte | 6 studies | 42% ± 13% | |
mast cell | 5 studies | 23% ± 8% | |
monocyte | 5 studies | 61% ± 8% | |
smooth muscle cell | 5 studies | 25% ± 6% | |
type I pneumocyte | 5 studies | 28% ± 6% | |
retina horizontal cell | 4 studies | 26% ± 10% | |
epithelial cell | 4 studies | 30% ± 13% | |
GABAergic interneuron | 3 studies | 38% ± 4% | |
non-classical monocyte | 3 studies | 24% ± 6% | |
alveolar macrophage | 3 studies | 59% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 6017.75 | 2626 / 2642 | 99% | 57.85 | 700 / 705 |
ovary | 100% | 5413.50 | 180 / 180 | 98% | 60.11 | 421 / 430 |
intestine | 99% | 2422.34 | 961 / 966 | 94% | 17.12 | 495 / 527 |
breast | 100% | 3553.29 | 458 / 459 | 94% | 29.72 | 1046 / 1118 |
stomach | 98% | 1864.35 | 351 / 359 | 95% | 17.46 | 271 / 286 |
skin | 89% | 2568.01 | 1611 / 1809 | 99% | 64.22 | 467 / 472 |
thymus | 96% | 1749.87 | 626 / 653 | 91% | 17.49 | 553 / 605 |
lung | 100% | 5991.54 | 578 / 578 | 85% | 16.90 | 984 / 1155 |
kidney | 92% | 1796.11 | 82 / 89 | 91% | 18.52 | 820 / 901 |
adrenal gland | 97% | 1741.62 | 250 / 258 | 83% | 39.64 | 192 / 230 |
esophagus | 99% | 2597.02 | 1435 / 1445 | 71% | 10.21 | 130 / 183 |
bladder | 100% | 3238.00 | 21 / 21 | 67% | 11.15 | 336 / 504 |
pancreas | 66% | 949.22 | 216 / 328 | 94% | 17.47 | 168 / 178 |
prostate | 95% | 2224.03 | 233 / 245 | 62% | 6.65 | 312 / 502 |
uterus | 100% | 5454.78 | 170 / 170 | 56% | 13.43 | 255 / 459 |
adipose | 100% | 4871.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6975.27 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 53.51 | 80 / 80 |
spleen | 100% | 3182.10 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.15 | 1 / 1 |
peripheral blood | 97% | 7138.15 | 900 / 929 | 0% | 0 | 0 / 0 |
heart | 95% | 2310.84 | 820 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 69% | 11.29 | 20 / 29 |
liver | 10% | 128.50 | 22 / 226 | 53% | 6.28 | 217 / 406 |
muscle | 51% | 789.09 | 413 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 47% | 5.02 | 21 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0043306 | Biological process | positive regulation of mast cell degranulation |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_0030316 | Biological process | osteoclast differentiation |
GO_0045121 | Cellular component | membrane raft |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
GO_0005515 | Molecular function | protein binding |
GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
GO_0005068 | Molecular function | transmembrane receptor protein tyrosine kinase adaptor activity |
Gene name | GAB2 |
Protein name | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) GRB2 associated binding protein 2 |
Synonyms | KIAA0571 |
Description | FUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. . |
Accessions | ENST00000530915.1 ENST00000340149.6 [Q9UQC2-2] ENST00000361507.5 [Q9UQC2-1] ENST00000528886.5 E9PJE2 E9PJ26 Q9UQC2 |