SRI | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	30% ± 9%	Explore
endothelial cell	31 studies	32% ± 14%	Explore
fibroblast	31 studies	35% ± 13%	Explore
B cell	28 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	27 studies	32% ± 14%	Explore
T cell	26 studies	28% ± 9%	Explore
CD4-positive, alpha-beta T cell	26 studies	29% ± 14%	Explore
smooth muscle cell	23 studies	27% ± 9%	Explore
macrophage	22 studies	25% ± 10%	Explore
pericyte	22 studies	32% ± 11%	Explore
conventional dendritic cell	21 studies	30% ± 12%	Explore
non-classical monocyte	20 studies	36% ± 14%	Explore
epithelial cell	20 studies	56% ± 20%	Explore
regulatory T cell	20 studies	32% ± 10%	Explore
basal cell	19 studies	42% ± 19%	Explore
mast cell	18 studies	34% ± 13%	Explore
ciliated cell	18 studies	74% ± 19%	Explore
classical monocyte	18 studies	25% ± 11%	Explore
connective tissue cell	18 studies	33% ± 13%	Explore
monocyte	17 studies	23% ± 7%	Explore
endothelial cell of lymphatic vessel	16 studies	44% ± 13%	Explore
mature NK T cell	16 studies	29% ± 7%	Explore
gamma-delta T cell	16 studies	31% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	27% ± 8%	Explore
plasmacytoid dendritic cell	14 studies	27% ± 10%	Explore
astrocyte	14 studies	35% ± 19%	Explore
memory B cell	14 studies	25% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	22% ± 5%	Explore
myofibroblast cell	13 studies	30% ± 11%	Explore
naive B cell	12 studies	21% ± 5%	Explore
capillary endothelial cell	12 studies	26% ± 8%	Explore
dendritic cell	12 studies	35% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 12%	Explore
secretory cell	11 studies	49% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	29% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	31% ± 8%	Explore
vein endothelial cell	11 studies	27% ± 7%	Explore
mucosal invariant T cell	11 studies	29% ± 6%	Explore
endothelial cell of vascular tree	11 studies	30% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 14%	Explore
endothelial cell of artery	10 studies	33% ± 9%	Explore
plasma cell	9 studies	32% ± 14%	Explore
club cell	9 studies	41% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	27% ± 10%	Explore
progenitor cell	9 studies	53% ± 22%	Explore
oligodendrocyte precursor cell	9 studies	31% ± 16%	Explore
type I pneumocyte	8 studies	33% ± 13%	Explore
abnormal cell	8 studies	39% ± 21%	Explore
goblet cell	8 studies	54% ± 11%	Explore
type II pneumocyte	7 studies	34% ± 17%	Explore
leukocyte	7 studies	24% ± 6%	Explore
neuron	7 studies	42% ± 18%	Explore
enterocyte	7 studies	63% ± 21%	Explore
mesothelial cell	7 studies	31% ± 18%	Explore
myeloid cell	7 studies	29% ± 11%	Explore
respiratory goblet cell	6 studies	40% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	44% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	37% ± 8%	Explore
renal alpha-intercalated cell	6 studies	54% ± 7%	Explore
erythrocyte	6 studies	42% ± 22%	Explore
T follicular helper cell	6 studies	25% ± 3%	Explore
innate lymphoid cell	6 studies	32% ± 8%	Explore
alveolar macrophage	5 studies	25% ± 5%	Explore
hematopoietic precursor cell	5 studies	45% ± 20%	Explore
plasmablast	5 studies	41% ± 22%	Explore
erythroblast	5 studies	49% ± 19%	Explore
hematopoietic stem cell	5 studies	36% ± 14%	Explore
oligodendrocyte	5 studies	21% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	45% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	36% ± 16%	Explore
glutamatergic neuron	5 studies	36% ± 16%	Explore
deuterosomal cell	4 studies	38% ± 11%	Explore
pancreatic A cell	4 studies	38% ± 13%	Explore
mononuclear phagocyte	4 studies	32% ± 12%	Explore
exhausted T cell	4 studies	46% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	47% ± 6%	Explore
epithelial cell of proximal tubule	4 studies	26% ± 7%	Explore
enteroendocrine cell	4 studies	45% ± 12%	Explore
intestinal crypt stem cell	4 studies	55% ± 8%	Explore
transit amplifying cell	4 studies	64% ± 15%	Explore
retinal ganglion cell	4 studies	53% ± 28%	Explore
precursor B cell	4 studies	27% ± 8%	Explore
brush cell	4 studies	34% ± 4%	Explore
adventitial cell	4 studies	29% ± 9%	Explore
mucus secreting cell	4 studies	32% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 9%	Explore
granulocyte	4 studies	41% ± 12%	Explore
GABAergic neuron	4 studies	29% ± 10%	Explore
group 3 innate lymphoid cell	4 studies	53% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 7%	Explore
duct epithelial cell	3 studies	27% ± 5%	Explore
ionocyte	3 studies	24% ± 5%	Explore
precursor cell	3 studies	52% ± 9%	Explore
type B pancreatic cell	3 studies	45% ± 8%	Explore
glomerular endothelial cell	3 studies	27% ± 5%	Explore
neural crest cell	3 studies	40% ± 6%	Explore
extravillous trophoblast	3 studies	58% ± 25%	Explore
lymphocyte	3 studies	41% ± 11%	Explore
neuroendocrine cell	3 studies	28% ± 7%	Explore
immature B cell	3 studies	23% ± 1%	Explore
microglial cell	3 studies	24% ± 6%	Explore
intraepithelial lymphocyte	3 studies	35% ± 4%	Explore
Mueller cell	3 studies	37% ± 11%	Explore
acinar cell	3 studies	39% ± 20%	Explore
muscle cell	3 studies	30% ± 15%	Explore
germinal center B cell	3 studies	25% ± 7%	Explore
intermediate monocyte	3 studies	40% ± 19%	Explore
CD4-positive helper T cell	3 studies	22% ± 6%	Explore
myoepithelial cell	3 studies	35% ± 8%	Explore
luminal cell of prostate epithelium	3 studies	27% ± 7%	Explore
pancreatic ductal cell	3 studies	56% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	55% ± 25%	Explore
glial cell	3 studies	46% ± 19%	Explore
T-helper 17 cell	3 studies	47% ± 24%	Explore
T-helper 1 cell	3 studies	43% ± 15%	Explore
double negative thymocyte	3 studies	42% ± 14%	Explore
interneuron	3 studies	26% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	36% ± 15%	Explore
peripheral blood	15 studies	29% ± 8%	Explore
intestine	13 studies	37% ± 21%	Explore
brain	10 studies	27% ± 9%	Explore
kidney	9 studies	28% ± 8%	Explore
eye	6 studies	22% ± 7%	Explore
bone marrow	5 studies	23% ± 4%	Explore
liver	5 studies	36% ± 22%	Explore
lymph node	5 studies	27% ± 8%	Explore
pancreas	4 studies	39% ± 12%	Explore
uterus	4 studies	46% ± 17%	Explore
prostate	4 studies	37% ± 14%	Explore
breast	4 studies	32% ± 4%	Explore
adrenal gland	3 studies	24% ± 5%	Explore
skin	3 studies	21% ± 4%	Explore
thymus	3 studies	39% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	8754.95	2642 / 2642	100%	288.97	705 / 705
ovary	100%	3284.62	180 / 180	100%	54.65	430 / 430
intestine	100%	6932.36	966 / 966	100%	95.81	526 / 527
stomach	100%	2313.53	358 / 359	100%	78.21	286 / 286
bladder	100%	3651.10	21 / 21	100%	83.07	502 / 504
prostate	100%	3490.49	245 / 245	100%	52.61	500 / 502
kidney	100%	3634.22	89 / 89	100%	59.43	897 / 901
breast	100%	4451.84	459 / 459	99%	63.69	1112 / 1118
esophagus	100%	2696.52	1444 / 1445	99%	52.88	182 / 183
uterus	100%	3552.14	170 / 170	99%	57.69	456 / 459
lung	99%	3493.97	574 / 578	100%	66.47	1154 / 1155
thymus	100%	3592.28	651 / 653	99%	49.86	600 / 605
skin	99%	3035.56	1794 / 1809	97%	50.55	460 / 472
adrenal gland	100%	3690.95	258 / 258	97%	50.78	222 / 230
pancreas	95%	1786.27	313 / 328	99%	72.10	177 / 178
adipose	100%	4276.26	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	77.03	29 / 29
spleen	100%	2708.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.23	45 / 45
ureter	0%	0	0 / 0	100%	30.76	1 / 1
blood vessel	100%	3936.40	1333 / 1335	0%	0	0 / 0
liver	43%	571.65	97 / 226	53%	14.71	214 / 406
heart	95%	2257.15	820 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	28.25	73 / 80
peripheral blood	88%	2390.00	816 / 929	0%	0	0 / 0
muscle	55%	654.30	438 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060315	Biological process	negative regulation of ryanodine-sensitive calcium-release channel activity
GO_0006942	Biological process	regulation of striated muscle contraction
GO_0051924	Biological process	regulation of calcium ion transport
GO_0007507	Biological process	heart development
GO_0006880	Biological process	intracellular sequestering of iron ion
GO_0086004	Biological process	regulation of cardiac muscle cell contraction
GO_0007165	Biological process	signal transduction
GO_0010459	Biological process	negative regulation of heart rate
GO_1901077	Biological process	regulation of relaxation of muscle
GO_0055118	Biological process	negative regulation of cardiac muscle contraction
GO_0035774	Biological process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0007517	Biological process	muscle organ development
GO_1901841	Biological process	regulation of high voltage-gated calcium channel activity
GO_0010649	Biological process	regulation of cell communication by electrical coupling
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0010880	Biological process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0001508	Biological process	action potential
GO_1901844	Biological process	regulation of cell communication by electrical coupling involved in cardiac conduction
GO_0008016	Biological process	regulation of heart contraction
GO_0006816	Biological process	calcium ion transport
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0030018	Cellular component	Z disc
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0042584	Cellular component	chromaffin granule membrane
GO_0030315	Cellular component	T-tubule
GO_0005829	Cellular component	cytosol
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0033017	Cellular component	sarcoplasmic reticulum membrane
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0005246	Molecular function	calcium channel regulator activity
GO_0005102	Molecular function	signaling receptor binding
GO_0002020	Molecular function	protease binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

Gene name	SRI
Protein name	Calcium binding protein amplified in mutlidrug-resistant cells Sorcin (22 kDa protein) (CP-22) (CP22) (V19) Sorcin
Synonyms
Description	FUNCTION: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. .
Accessions	ENST00000490437.5 ENST00000265729.7 [P30626-1] ENST00000419179.5 Q75MZ6 ENST00000457606.5 P30626 ENST00000431660.5 [P30626-3] B4DHQ6 ENST00000394641.7 [P30626-2] E9PG82 C9J0K6

SRI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review