ARHGAP11B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ARHGAP11B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARHGAP11B at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0021987Biological processcerebral cortex development
GO_0006543Biological processglutamine catabolic process
GO_0043547Biological processpositive regulation of GTPase activity
GO_0035795Biological processnegative regulation of mitochondrial membrane permeability
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameARHGAP11B
Protein nameInactive Rho GTPase-activating protein 11B (Rho-type GTPase-activating protein 11B)
ARHGAP11B
SynonymsFAM7B1
DescriptionFUNCTION: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex . Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion . Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation . Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development . .

AccessionsENST00000697964.2
Q3KRB8
ENST00000650801.2
A0A2X0SFT2
ENST00000651601.2
ENST00000693711.1
ENST00000621228.1
ENST00000428041.4