Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 25% ± 10% | |
classical monocyte | 9 studies | 19% ± 3% | |
non-classical monocyte | 9 studies | 19% ± 4% | |
dendritic cell | 8 studies | 23% ± 8% | |
glutamatergic neuron | 8 studies | 36% ± 25% | |
macrophage | 8 studies | 25% ± 8% | |
conventional dendritic cell | 7 studies | 24% ± 6% | |
astrocyte | 7 studies | 30% ± 12% | |
monocyte | 6 studies | 24% ± 4% | |
microglial cell | 6 studies | 25% ± 6% | |
epithelial cell | 6 studies | 37% ± 20% | |
GABAergic neuron | 6 studies | 37% ± 19% | |
adipocyte | 5 studies | 20% ± 2% | |
interneuron | 5 studies | 34% ± 22% | |
squamous epithelial cell | 4 studies | 34% ± 17% | |
neuron | 4 studies | 24% ± 8% | |
myeloid cell | 4 studies | 22% ± 3% | |
oligodendrocyte precursor cell | 4 studies | 30% ± 8% | |
endothelial cell of lymphatic vessel | 4 studies | 19% ± 3% | |
oligodendrocyte | 4 studies | 25% ± 6% | |
granule cell | 3 studies | 18% ± 2% | |
lymphocyte | 3 studies | 21% ± 3% | |
alveolar macrophage | 3 studies | 27% ± 8% | |
type I pneumocyte | 3 studies | 21% ± 5% | |
basal cell | 3 studies | 33% ± 19% | |
transit amplifying cell | 3 studies | 33% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 3726.10 | 459 / 459 | 100% | 36.71 | 1118 / 1118 |
esophagus | 100% | 4848.63 | 1445 / 1445 | 100% | 38.10 | 183 / 183 |
intestine | 100% | 3687.21 | 966 / 966 | 100% | 33.26 | 527 / 527 |
lung | 100% | 3601.59 | 578 / 578 | 100% | 29.77 | 1155 / 1155 |
ovary | 100% | 3483.24 | 180 / 180 | 100% | 25.32 | 430 / 430 |
prostate | 100% | 3543.82 | 245 / 245 | 100% | 32.25 | 502 / 502 |
bladder | 100% | 4330.24 | 21 / 21 | 100% | 36.73 | 503 / 504 |
stomach | 100% | 2603.39 | 359 / 359 | 100% | 29.86 | 285 / 286 |
skin | 100% | 5203.51 | 1809 / 1809 | 100% | 32.49 | 470 / 472 |
uterus | 100% | 3303.02 | 170 / 170 | 100% | 36.25 | 457 / 459 |
kidney | 100% | 3148.01 | 89 / 89 | 100% | 30.44 | 897 / 901 |
thymus | 100% | 3441.45 | 653 / 653 | 100% | 28.24 | 602 / 605 |
brain | 99% | 1895.72 | 2610 / 2642 | 100% | 27.54 | 705 / 705 |
pancreas | 98% | 1545.14 | 322 / 328 | 99% | 31.75 | 177 / 178 |
adrenal gland | 100% | 3688.84 | 258 / 258 | 97% | 16.46 | 222 / 230 |
liver | 100% | 1904.53 | 226 / 226 | 94% | 14.63 | 383 / 406 |
adipose | 100% | 4032.34 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4098.21 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 32.00 | 29 / 29 |
muscle | 100% | 4688.56 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3368.23 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 36.62 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 20.93 | 1 / 1 |
peripheral blood | 99% | 4451.10 | 918 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 2428.70 | 839 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 11.23 | 69 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070294 | Biological process | renal sodium ion absorption |
GO_0038146 | Biological process | chemokine (C-X-C motif) ligand 12 signaling pathway |
GO_0071476 | Biological process | cellular hypotonic response |
GO_1901380 | Biological process | negative regulation of potassium ion transmembrane transport |
GO_0007165 | Biological process | signal transduction |
GO_0038116 | Biological process | chemokine (C-C motif) ligand 21 signaling pathway |
GO_0010820 | Biological process | positive regulation of T cell chemotaxis |
GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
GO_0006884 | Biological process | cell volume homeostasis |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0007231 | Biological process | osmosensory signaling pathway |
GO_1990869 | Biological process | cellular response to chemokine |
GO_1901017 | Biological process | negative regulation of potassium ion transmembrane transporter activity |
GO_0071474 | Biological process | cellular hyperosmotic response |
GO_0006468 | Biological process | protein phosphorylation |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0006979 | Biological process | response to oxidative stress |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | OXSR1 |
Protein name | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) Alternative protein OXSR1 |
Synonyms | KIAA1101 OSR1 |
Description | FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure . Specifically recognizes and binds proteins with a RFXV motif . Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity . Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases . Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux . Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 . Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 . Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation . Phosphorylates RELL1, RELL2 and RELT . Phosphorylates PAK1 . Phosphorylates PLSCR1 in the presence of RELT . . |
Accessions | L8ECC0 ENST00000426620.5 ENST00000311806.8 C9JIG9 ENST00000446845.5 F8WBK9 O95747 |