OXSR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070294Biological processrenal sodium ion absorption
GO_0038146Biological processchemokine (C-X-C motif) ligand 12 signaling pathway
GO_0071476Biological processcellular hypotonic response
GO_1901380Biological processnegative regulation of potassium ion transmembrane transport
GO_0007165Biological processsignal transduction
GO_0038116Biological processchemokine (C-C motif) ligand 21 signaling pathway
GO_0010820Biological processpositive regulation of T cell chemotaxis
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0006884Biological processcell volume homeostasis
GO_0035556Biological processintracellular signal transduction
GO_0007231Biological processosmosensory signaling pathway
GO_1990869Biological processcellular response to chemokine
GO_1901017Biological processnegative regulation of potassium ion transmembrane transporter activity
GO_0071474Biological processcellular hyperosmotic response
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0046777Biological processprotein autophosphorylation
GO_0006979Biological processresponse to oxidative stress
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOXSR1
Protein nameSerine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)
Alternative protein OXSR1
SynonymsKIAA1101
OSR1
DescriptionFUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure . Specifically recognizes and binds proteins with a RFXV motif . Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity . Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases . Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux . Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 . Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 . Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation . Phosphorylates RELL1, RELL2 and RELT . Phosphorylates PAK1 . Phosphorylates PLSCR1 in the presence of RELT . .

AccessionsL8ECC0
ENST00000426620.5
ENST00000311806.8
C9JIG9
ENST00000446845.5
F8WBK9
O95747