FNBP1L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	31% ± 15%	Explore
epithelial cell	13 studies	36% ± 18%	Explore
capillary endothelial cell	12 studies	25% ± 8%	Explore
astrocyte	11 studies	32% ± 14%	Explore
pericyte	11 studies	30% ± 15%	Explore
type I pneumocyte	10 studies	37% ± 13%	Explore
neuron	9 studies	49% ± 25%	Explore
GABAergic neuron	9 studies	54% ± 22%	Explore
glutamatergic neuron	9 studies	52% ± 21%	Explore
microglial cell	9 studies	33% ± 13%	Explore
basal cell	9 studies	31% ± 15%	Explore
ciliated cell	9 studies	27% ± 11%	Explore
oligodendrocyte precursor cell	8 studies	26% ± 7%	Explore
endothelial cell of lymphatic vessel	7 studies	24% ± 5%	Explore
interneuron	7 studies	63% ± 13%	Explore
club cell	7 studies	36% ± 12%	Explore
type II pneumocyte	7 studies	29% ± 9%	Explore
adipocyte	7 studies	23% ± 5%	Explore
fibroblast	6 studies	17% ± 2%	Explore
retina horizontal cell	5 studies	40% ± 19%	Explore
endothelial cell of artery	5 studies	19% ± 2%	Explore
vein endothelial cell	5 studies	35% ± 21%	Explore
abnormal cell	4 studies	24% ± 9%	Explore
brush cell	4 studies	31% ± 6%	Explore
smooth muscle cell	4 studies	20% ± 2%	Explore
endothelial cell of vascular tree	4 studies	35% ± 16%	Explore
enteroendocrine cell	4 studies	26% ± 8%	Explore
respiratory goblet cell	4 studies	41% ± 14%	Explore
goblet cell	4 studies	24% ± 11%	Explore
kidney loop of Henle epithelial cell	4 studies	31% ± 9%	Explore
renal alpha-intercalated cell	4 studies	42% ± 18%	Explore
renal principal cell	4 studies	33% ± 8%	Explore
GABAergic interneuron	3 studies	54% ± 22%	Explore
macrophage	3 studies	42% ± 13%	Explore
progenitor cell	3 studies	49% ± 14%	Explore
myofibroblast cell	3 studies	23% ± 8%	Explore
glycinergic amacrine cell	3 studies	30% ± 16%	Explore
neural progenitor cell	3 studies	50% ± 7%	Explore
connective tissue cell	3 studies	22% ± 5%	Explore
transit amplifying cell	3 studies	31% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	28% ± 7%	Explore
mucus secreting cell	3 studies	41% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	44% ± 17%	Explore
lung	8 studies	21% ± 4%	Explore
kidney	4 studies	29% ± 9%	Explore
intestine	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3049.17	245 / 245	99%	61.27	499 / 502
breast	100%	5058.74	459 / 459	99%	80.20	1110 / 1118
ovary	100%	2412.51	180 / 180	99%	38.53	425 / 430
kidney	100%	4847.80	89 / 89	99%	54.18	888 / 901
lung	100%	3735.12	578 / 578	98%	40.07	1134 / 1155
intestine	100%	2540.70	964 / 966	98%	41.35	514 / 527
pancreas	100%	2194.34	328 / 328	97%	37.87	173 / 178
thymus	100%	5207.12	653 / 653	96%	54.11	578 / 605
stomach	98%	2634.58	353 / 359	97%	41.84	278 / 286
esophagus	100%	1579.63	1439 / 1445	96%	37.28	175 / 183
uterus	100%	2896.45	170 / 170	92%	35.83	423 / 459
bladder	95%	2279.81	20 / 21	95%	39.29	479 / 504
brain	99%	2469.81	2628 / 2642	87%	29.81	615 / 705
skin	100%	2495.22	1805 / 1809	81%	24.56	384 / 472
liver	100%	1239.94	225 / 226	68%	17.53	275 / 406
adrenal gland	100%	1626.83	257 / 258	64%	11.18	147 / 230
adipose	100%	3993.65	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	17.12	1 / 1
heart	100%	2076.03	860 / 861	0%	0	0 / 0
muscle	100%	2041.55	802 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	20.52	38 / 45
blood vessel	82%	1094.25	1098 / 1335	0%	0	0 / 0
spleen	58%	463.30	140 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	39%	7.63	31 / 80
lymph node	0%	0	0 / 0	3%	0.66	1 / 29
peripheral blood	0%	2.88	4 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_0007165	Biological process	signal transduction
GO_0010324	Biological process	membrane invagination
GO_0030050	Biological process	vesicle transport along actin filament
GO_0097320	Biological process	plasma membrane tubulation
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_0016050	Biological process	vesicle organization
GO_0006900	Biological process	vesicle budding from membrane
GO_0006914	Biological process	autophagy
GO_0072583	Biological process	clathrin-dependent endocytosis
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0008289	Molecular function	lipid binding
GO_0045296	Molecular function	cadherin binding
GO_0051020	Molecular function	GTPase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FNBP1L
Protein name	Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) Formin binding protein 1 like
Synonyms	C1orf39 TOCA1
Description	FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. .
Accessions	ENST00000271234.13 [Q5T0N5-1] ENST00000370253.6 [Q5T0N5-3] Q5T0N5 ENST00000424449.2 A0A075B6Q2 ENST00000260506.12 [Q5T0N5-4]

FNBP1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review