NFAT5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	41% ± 17%	Explore
fibroblast	25 studies	36% ± 17%	Explore
endothelial cell of lymphatic vessel	20 studies	45% ± 22%	Explore
pericyte	19 studies	35% ± 16%	Explore
astrocyte	19 studies	56% ± 21%	Explore
smooth muscle cell	17 studies	33% ± 13%	Explore
macrophage	15 studies	34% ± 18%	Explore
microglial cell	15 studies	43% ± 14%	Explore
basal cell	14 studies	38% ± 22%	Explore
oligodendrocyte precursor cell	14 studies	44% ± 17%	Explore
oligodendrocyte	14 studies	36% ± 13%	Explore
mast cell	14 studies	30% ± 13%	Explore
natural killer cell	12 studies	25% ± 9%	Explore
glutamatergic neuron	12 studies	59% ± 24%	Explore
B cell	11 studies	24% ± 9%	Explore
T cell	11 studies	27% ± 11%	Explore
epithelial cell	11 studies	41% ± 23%	Explore
GABAergic neuron	11 studies	52% ± 23%	Explore
regulatory T cell	11 studies	23% ± 8%	Explore
adipocyte	10 studies	51% ± 13%	Explore
dendritic cell	9 studies	37% ± 11%	Explore
type I pneumocyte	9 studies	42% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 8%	Explore
capillary endothelial cell	9 studies	26% ± 9%	Explore
myeloid cell	9 studies	29% ± 7%	Explore
ciliated cell	9 studies	34% ± 15%	Explore
monocyte	8 studies	34% ± 14%	Explore
endothelial cell of artery	8 studies	32% ± 13%	Explore
type II pneumocyte	7 studies	44% ± 17%	Explore
non-classical monocyte	7 studies	27% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 6%	Explore
neuron	7 studies	47% ± 22%	Explore
club cell	7 studies	43% ± 19%	Explore
vein endothelial cell	7 studies	38% ± 22%	Explore
endothelial cell of vascular tree	7 studies	36% ± 20%	Explore
connective tissue cell	7 studies	26% ± 12%	Explore
secretory cell	6 studies	25% ± 10%	Explore
classical monocyte	6 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	20% ± 5%	Explore
interneuron	6 studies	60% ± 21%	Explore
CD8-positive, alpha-beta T cell	6 studies	22% ± 5%	Explore
mesothelial cell	6 studies	37% ± 14%	Explore
respiratory goblet cell	5 studies	46% ± 21%	Explore
CD4-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
mature NK T cell	5 studies	24% ± 13%	Explore
cardiac muscle cell	5 studies	48% ± 13%	Explore
lymphocyte	5 studies	38% ± 12%	Explore
Mueller cell	5 studies	40% ± 13%	Explore
retina horizontal cell	5 studies	32% ± 9%	Explore
goblet cell	5 studies	38% ± 29%	Explore
conventional dendritic cell	4 studies	25% ± 6%	Explore
progenitor cell	4 studies	25% ± 9%	Explore
granule cell	4 studies	43% ± 10%	Explore
retinal pigment epithelial cell	4 studies	48% ± 25%	Explore
amacrine cell	4 studies	35% ± 3%	Explore
retinal cone cell	4 studies	42% ± 11%	Explore
retinal rod cell	4 studies	41% ± 8%	Explore
myofibroblast cell	4 studies	40% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	18% ± 3%	Explore
myoepithelial cell	4 studies	38% ± 25%	Explore
renal principal cell	4 studies	50% ± 21%	Explore
ionocyte	3 studies	25% ± 5%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
renal beta-intercalated cell	3 studies	35% ± 11%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	44% ± 1%	Explore
GABAergic interneuron	3 studies	49% ± 3%	Explore
glial cell	3 studies	25% ± 7%	Explore
plasma cell	3 studies	32% ± 7%	Explore
mononuclear phagocyte	3 studies	31% ± 6%	Explore
mucosal invariant T cell	3 studies	25% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
GABAergic amacrine cell	3 studies	39% ± 5%	Explore
ON-bipolar cell	3 studies	31% ± 11%	Explore
glycinergic amacrine cell	3 studies	33% ± 4%	Explore
retinal ganglion cell	3 studies	35% ± 8%	Explore
rod bipolar cell	3 studies	40% ± 11%	Explore
naive B cell	3 studies	17% ± 0%	Explore
hepatocyte	3 studies	59% ± 16%	Explore
abnormal cell	3 studies	43% ± 25%	Explore
ependymal cell	3 studies	58% ± 18%	Explore
leukocyte	3 studies	35% ± 13%	Explore
alveolar macrophage	3 studies	41% ± 8%	Explore
gamma-delta T cell	3 studies	22% ± 5%	Explore
Schwann cell	3 studies	33% ± 12%	Explore
muscle cell	3 studies	45% ± 27%	Explore
brush cell	3 studies	24% ± 4%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 6%	Explore
kidney loop of Henle epithelial cell	3 studies	32% ± 13%	Explore
renal alpha-intercalated cell	3 studies	46% ± 22%	Explore
mucus secreting cell	3 studies	42% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	47% ± 20%	Explore
lung	10 studies	32% ± 13%	Explore
eye	6 studies	41% ± 20%	Explore
heart	5 studies	38% ± 12%	Explore
kidney	5 studies	34% ± 15%	Explore
intestine	4 studies	18% ± 2%	Explore
adipose	4 studies	40% ± 18%	Explore
peripheral blood	3 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4320.90	1440 / 1445	100%	22.37	183 / 183
lung	100%	4865.79	578 / 578	97%	9.55	1115 / 1155
stomach	99%	2917.86	356 / 359	97%	13.81	278 / 286
intestine	100%	3945.15	964 / 966	95%	9.92	503 / 527
kidney	100%	3478.65	89 / 89	93%	14.11	837 / 901
breast	100%	5100.27	458 / 459	92%	9.71	1024 / 1118
pancreas	98%	2331.92	323 / 328	92%	8.47	164 / 178
skin	100%	6084.94	1808 / 1809	89%	8.51	421 / 472
thymus	100%	6890.45	652 / 653	87%	11.51	526 / 605
bladder	100%	4623.95	21 / 21	86%	8.52	434 / 504
adrenal gland	100%	5459.64	258 / 258	84%	6.77	193 / 230
prostate	100%	4147.78	244 / 245	84%	8.12	423 / 502
ovary	100%	4203.37	180 / 180	82%	4.70	352 / 430
brain	88%	1910.66	2335 / 2642	93%	8.08	653 / 705
uterus	100%	5852.20	170 / 170	78%	6.09	359 / 459
liver	87%	1409.40	196 / 226	42%	2.01	169 / 406
adipose	100%	4729.83	1203 / 1204	0%	0	0 / 0
blood vessel	100%	4389.88	1333 / 1335	0%	0	0 / 0
spleen	99%	2664.66	239 / 241	0%	0	0 / 0
muscle	99%	2125.29	793 / 803	0%	0	0 / 0
heart	91%	2034.59	785 / 861	0%	0	0 / 0
peripheral blood	75%	2646.21	700 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	73%	5.34	33 / 45
eye	0%	0	0 / 0	66%	4.03	53 / 80
lymph node	0%	0	0 / 0	55%	4.62	16 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0006974	Biological process	DNA damage response
GO_0001816	Biological process	cytokine production
GO_0033173	Biological process	calcineurin-NFAT signaling cascade
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0062176	Biological process	R-loop processing
GO_0071474	Biological process	cellular hyperosmotic response
GO_1904996	Biological process	positive regulation of leukocyte adhesion to vascular endothelial cell
GO_0070884	Biological process	regulation of calcineurin-NFAT signaling cascade
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0008134	Molecular function	transcription factor binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NFAT5
Protein name	Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Nuclear factor of activated T cells 5
Synonyms	TONEBP KIAA0827
Description	FUNCTION: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' . Mediates the transcriptional response to hypertonicity . Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 . Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA . .
Accessions	ENST00000650987.1 ENST00000567239.5 [O94916-4] A0A499FIS8 A0A499FJX5 ENST00000349945.7 [O94916-5] ENST00000393742.7 ENST00000426654.6 [O94916-3] ENST00000567990.5 ENST00000563474.2 J3QKS5 ENST00000565301.2 H3BP21 ENST00000566899.6 O94916 J3KRL6 ENST00000354436.6 [O94916-1] ENST00000627621.3 A0A494C020

NFAT5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review