Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 27 studies | 31% ± 13% | |
astrocyte | 11 studies | 28% ± 14% | |
oligodendrocyte | 11 studies | 35% ± 13% | |
glutamatergic neuron | 9 studies | 36% ± 23% | |
fibroblast | 8 studies | 25% ± 9% | |
ciliated cell | 7 studies | 25% ± 7% | |
microglial cell | 7 studies | 29% ± 9% | |
epithelial cell | 7 studies | 35% ± 19% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 10% | |
neuron | 6 studies | 35% ± 14% | |
macrophage | 6 studies | 30% ± 8% | |
oligodendrocyte precursor cell | 6 studies | 27% ± 11% | |
vein endothelial cell | 6 studies | 27% ± 16% | |
GABAergic neuron | 6 studies | 36% ± 20% | |
type I pneumocyte | 5 studies | 22% ± 6% | |
interneuron | 5 studies | 37% ± 21% | |
basal cell | 5 studies | 33% ± 20% | |
adipocyte | 5 studies | 24% ± 3% | |
alveolar macrophage | 5 studies | 31% ± 8% | |
pericyte | 5 studies | 25% ± 7% | |
smooth muscle cell | 5 studies | 23% ± 4% | |
ionocyte | 3 studies | 30% ± 9% | |
glial cell | 3 studies | 19% ± 5% | |
granule cell | 3 studies | 20% ± 2% | |
squamous epithelial cell | 3 studies | 40% ± 20% | |
club cell | 3 studies | 20% ± 5% | |
respiratory goblet cell | 3 studies | 23% ± 5% | |
secretory cell | 3 studies | 27% ± 5% | |
endothelial cell of vascular tree | 3 studies | 32% ± 16% | |
hepatocyte | 3 studies | 34% ± 18% | |
connective tissue cell | 3 studies | 19% ± 3% | |
capillary endothelial cell | 3 studies | 23% ± 4% | |
renal principal cell | 3 studies | 24% ± 8% | |
endothelial cell of artery | 3 studies | 20% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 10625.62 | 1445 / 1445 | 100% | 75.77 | 183 / 183 |
stomach | 100% | 7799.65 | 359 / 359 | 99% | 48.11 | 284 / 286 |
intestine | 100% | 10776.89 | 966 / 966 | 98% | 44.77 | 517 / 527 |
brain | 100% | 10213.47 | 2642 / 2642 | 98% | 55.85 | 689 / 705 |
lung | 100% | 10370.64 | 578 / 578 | 98% | 43.98 | 1128 / 1155 |
ovary | 100% | 9731.99 | 180 / 180 | 97% | 41.64 | 418 / 430 |
breast | 100% | 9878.33 | 459 / 459 | 97% | 49.53 | 1082 / 1118 |
pancreas | 99% | 4530.72 | 324 / 328 | 98% | 49.22 | 174 / 178 |
skin | 100% | 10257.80 | 1809 / 1809 | 96% | 43.95 | 453 / 472 |
prostate | 100% | 9387.19 | 245 / 245 | 95% | 44.84 | 477 / 502 |
kidney | 100% | 9610.64 | 89 / 89 | 94% | 47.71 | 848 / 901 |
bladder | 100% | 10528.57 | 21 / 21 | 93% | 33.01 | 471 / 504 |
thymus | 100% | 9210.77 | 653 / 653 | 91% | 38.91 | 551 / 605 |
uterus | 100% | 11451.60 | 170 / 170 | 91% | 35.92 | 416 / 459 |
adrenal gland | 100% | 9011.98 | 258 / 258 | 85% | 28.85 | 196 / 230 |
liver | 100% | 4831.88 | 226 / 226 | 76% | 19.21 | 310 / 406 |
adipose | 100% | 10393.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9873.12 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 6016.30 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.06 | 1 / 1 |
heart | 100% | 6574.17 | 858 / 861 | 0% | 0 | 0 / 0 |
muscle | 100% | 4714.43 | 799 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 44.68 | 78 / 80 |
tonsil | 0% | 0 | 0 / 0 | 91% | 36.26 | 41 / 45 |
lymph node | 0% | 0 | 0 / 0 | 41% | 6.34 | 12 / 29 |
peripheral blood | 16% | 492.87 | 150 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0007163 | Biological process | establishment or maintenance of cell polarity |
GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0031032 | Biological process | actomyosin structure organization |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0006468 | Biological process | protein phosphorylation |
GO_0016477 | Biological process | cell migration |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0031252 | Cellular component | cell leading edge |
GO_0005911 | Cellular component | cell-cell junction |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0042641 | Cellular component | actomyosin |
GO_0030027 | Cellular component | lamellipodium |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | CDC42BPB |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) |
Synonyms | KIAA1124 |
Description | FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 . In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration . Phosphorylates PPP1R12A . In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). . |
Accessions | H0YLY0 A0A0U1RRC3 Q9Y5S2 Q86XZ8 ENST00000361246.7 ENST00000559043.2 ENST00000558321.5 |