CDC42BPB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0007010Biological processcytoskeleton organization
GO_0031032Biological processactomyosin structure organization
GO_0030036Biological processactin cytoskeleton organization
GO_0006468Biological processprotein phosphorylation
GO_0016477Biological processcell migration
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0031252Cellular componentcell leading edge
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042641Cellular componentactomyosin
GO_0030027Cellular componentlamellipodium
GO_0106310Molecular functionprotein serine kinase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCDC42BPB
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
SynonymsKIAA1124
DescriptionFUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 . In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration . Phosphorylates PPP1R12A . In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). .

AccessionsH0YLY0
A0A0U1RRC3
Q9Y5S2
Q86XZ8
ENST00000361246.7
ENST00000559043.2
ENST00000558321.5