Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 44 studies | 47% ± 19% | |
endothelial cell | 41 studies | 41% ± 17% | |
smooth muscle cell | 24 studies | 31% ± 11% | |
pericyte | 19 studies | 40% ± 22% | |
astrocyte | 18 studies | 52% ± 21% | |
endothelial cell of lymphatic vessel | 16 studies | 24% ± 6% | |
connective tissue cell | 16 studies | 40% ± 13% | |
endothelial cell of vascular tree | 14 studies | 35% ± 20% | |
oligodendrocyte precursor cell | 12 studies | 42% ± 19% | |
vein endothelial cell | 12 studies | 30% ± 9% | |
myofibroblast cell | 11 studies | 28% ± 11% | |
capillary endothelial cell | 10 studies | 33% ± 16% | |
oligodendrocyte | 9 studies | 27% ± 10% | |
endothelial cell of artery | 9 studies | 23% ± 8% | |
adipocyte | 8 studies | 33% ± 21% | |
endothelial cell of sinusoid | 5 studies | 50% ± 20% | |
macrophage | 5 studies | 18% ± 2% | |
epithelial cell | 5 studies | 26% ± 9% | |
adventitial cell | 5 studies | 38% ± 17% | |
basal cell | 4 studies | 19% ± 4% | |
glomerular endothelial cell | 4 studies | 94% ± 1% | |
cardiac muscle cell | 4 studies | 35% ± 7% | |
hepatocyte | 4 studies | 61% ± 32% | |
GABAergic neuron | 3 studies | 27% ± 5% | |
myeloid cell | 3 studies | 19% ± 2% | |
Mueller cell | 3 studies | 25% ± 4% | |
muscle cell | 3 studies | 42% ± 3% | |
abnormal cell | 3 studies | 37% ± 5% | |
ependymal cell | 3 studies | 35% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 34205.41 | 653 / 653 | 97% | 411.67 | 587 / 605 |
kidney | 100% | 10403.55 | 89 / 89 | 94% | 112.52 | 843 / 901 |
prostate | 99% | 14431.99 | 242 / 245 | 94% | 47.21 | 470 / 502 |
breast | 100% | 23152.68 | 459 / 459 | 85% | 30.77 | 953 / 1118 |
lung | 99% | 13737.06 | 575 / 578 | 85% | 28.09 | 981 / 1155 |
brain | 85% | 8106.46 | 2249 / 2642 | 99% | 116.87 | 698 / 705 |
liver | 96% | 6326.46 | 217 / 226 | 85% | 38.40 | 346 / 406 |
adrenal gland | 98% | 7756.55 | 252 / 258 | 72% | 30.30 | 165 / 230 |
ovary | 99% | 12621.43 | 179 / 180 | 64% | 24.63 | 275 / 430 |
uterus | 100% | 17133.61 | 170 / 170 | 62% | 25.84 | 284 / 459 |
stomach | 98% | 8534.34 | 353 / 359 | 63% | 18.49 | 180 / 286 |
esophagus | 92% | 9444.42 | 1333 / 1445 | 67% | 20.49 | 122 / 183 |
bladder | 100% | 22851.67 | 21 / 21 | 58% | 16.65 | 291 / 504 |
intestine | 98% | 8603.29 | 943 / 966 | 47% | 11.93 | 246 / 527 |
pancreas | 57% | 2252.83 | 186 / 328 | 82% | 27.51 | 146 / 178 |
skin | 98% | 16357.52 | 1778 / 1809 | 36% | 12.64 | 168 / 472 |
adipose | 100% | 24828.12 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 15514.47 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 8025.36 | 828 / 861 | 0% | 0 | 0 / 0 |
muscle | 75% | 4231.26 | 606 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 64% | 26.25 | 29 / 45 |
spleen | 61% | 2557.74 | 148 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 41% | 9.46 | 12 / 29 |
eye | 0% | 0 | 0 / 0 | 3% | 0.44 | 2 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006670 | Biological process | sphingosine metabolic process |
GO_1902068 | Biological process | regulation of sphingolipid mediated signaling pathway |
GO_0006890 | Biological process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
GO_0060020 | Biological process | Bergmann glial cell differentiation |
GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
GO_0033631 | Biological process | cell-cell adhesion mediated by integrin |
GO_0007165 | Biological process | signal transduction |
GO_0010595 | Biological process | positive regulation of endothelial cell migration |
GO_0006672 | Biological process | ceramide metabolic process |
GO_0046839 | Biological process | phospholipid dephosphorylation |
GO_0042060 | Biological process | wound healing |
GO_0034109 | Biological process | homotypic cell-cell adhesion |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0030149 | Biological process | sphingolipid catabolic process |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
GO_0050821 | Biological process | protein stabilization |
GO_0001568 | Biological process | blood vessel development |
GO_0006644 | Biological process | phospholipid metabolic process |
GO_0030111 | Biological process | regulation of Wnt signaling pathway |
GO_0098609 | Biological process | cell-cell adhesion |
GO_0022409 | Biological process | positive regulation of cell-cell adhesion |
GO_0001702 | Biological process | gastrulation with mouth forming second |
GO_0005886 | Cellular component | plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0070971 | Cellular component | endoplasmic reticulum exit site |
GO_0005802 | Cellular component | trans-Golgi network |
GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005912 | Cellular component | adherens junction |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0008195 | Molecular function | phosphatidate phosphatase activity |
GO_0005178 | Molecular function | integrin binding |
GO_0106235 | Molecular function | ceramide-1-phosphate phosphatase activity |
GO_0042392 | Molecular function | sphingosine-1-phosphate phosphatase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PLPP3 |
Protein name | Phospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) |
Synonyms | LPP3 PPAP2B |
Description | FUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P . Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound . Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes . Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines . By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers . .; FUNCTION: Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth . Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis . . |
Accessions | ENST00000371250.4 O14495 |