PLPP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006670Biological processsphingosine metabolic process
GO_1902068Biological processregulation of sphingolipid mediated signaling pathway
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0060020Biological processBergmann glial cell differentiation
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0033631Biological processcell-cell adhesion mediated by integrin
GO_0007165Biological processsignal transduction
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0006672Biological processceramide metabolic process
GO_0046839Biological processphospholipid dephosphorylation
GO_0042060Biological processwound healing
GO_0034109Biological processhomotypic cell-cell adhesion
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0030149Biological processsphingolipid catabolic process
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0050821Biological processprotein stabilization
GO_0001568Biological processblood vessel development
GO_0006644Biological processphospholipid metabolic process
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0098609Biological processcell-cell adhesion
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0001702Biological processgastrulation with mouth forming second
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0005802Cellular componenttrans-Golgi network
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005912Cellular componentadherens junction
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008195Molecular functionphosphatidate phosphatase activity
GO_0005178Molecular functionintegrin binding
GO_0106235Molecular functionceramide-1-phosphate phosphatase activity
GO_0042392Molecular functionsphingosine-1-phosphate phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLPP3
Protein namePhospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP)
SynonymsLPP3
PPAP2B
DescriptionFUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P . Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound . Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes . Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines . By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers . .; FUNCTION: Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth . Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis . .

AccessionsENST00000371250.4
O14495