LYN | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	40 studies	38% ± 17%	Explore
B cell	36 studies	38% ± 14%	Explore
classical monocyte	27 studies	45% ± 16%	Explore
conventional dendritic cell	25 studies	35% ± 17%	Explore
non-classical monocyte	25 studies	71% ± 17%	Explore
monocyte	23 studies	48% ± 19%	Explore
natural killer cell	21 studies	24% ± 7%	Explore
dendritic cell	20 studies	42% ± 21%	Explore
endothelial cell of lymphatic vessel	19 studies	35% ± 13%	Explore
plasmacytoid dendritic cell	19 studies	42% ± 16%	Explore
naive B cell	18 studies	40% ± 15%	Explore
memory B cell	17 studies	39% ± 11%	Explore
myeloid cell	17 studies	45% ± 19%	Explore
mast cell	15 studies	27% ± 13%	Explore
microglial cell	15 studies	51% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	31% ± 9%	Explore
ciliated cell	10 studies	21% ± 7%	Explore
neutrophil	10 studies	43% ± 11%	Explore
alveolar macrophage	8 studies	36% ± 21%	Explore
type I pneumocyte	8 studies	25% ± 7%	Explore
club cell	8 studies	26% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 6%	Explore
endothelial cell	8 studies	23% ± 4%	Explore
epithelial cell	7 studies	25% ± 11%	Explore
hematopoietic precursor cell	6 studies	40% ± 21%	Explore
respiratory goblet cell	6 studies	43% ± 13%	Explore
mononuclear phagocyte	6 studies	43% ± 8%	Explore
astrocyte	6 studies	26% ± 9%	Explore
type II pneumocyte	6 studies	32% ± 4%	Explore
basal cell	6 studies	28% ± 13%	Explore
precursor B cell	5 studies	38% ± 11%	Explore
immature B cell	5 studies	50% ± 16%	Explore
intermediate monocyte	5 studies	52% ± 21%	Explore
secretory cell	4 studies	27% ± 11%	Explore
plasmablast	4 studies	29% ± 7%	Explore
platelet	4 studies	22% ± 4%	Explore
mature NK T cell	4 studies	21% ± 2%	Explore
leukocyte	4 studies	34% ± 14%	Explore
innate lymphoid cell	4 studies	18% ± 1%	Explore
lymphocyte	4 studies	20% ± 3%	Explore
inflammatory macrophage	4 studies	35% ± 15%	Explore
hematopoietic stem cell	4 studies	39% ± 17%	Explore
squamous epithelial cell	3 studies	38% ± 22%	Explore
monocyte-derived dendritic cell	3 studies	56% ± 23%	Explore
megakaryocyte	3 studies	40% ± 2%	Explore
plasma cell	3 studies	30% ± 11%	Explore
tissue-resident macrophage	3 studies	44% ± 10%	Explore
Mueller cell	3 studies	32% ± 6%	Explore
germinal center B cell	3 studies	43% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	66% ± 5%	Explore
mucus secreting cell	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	29% ± 12%	Explore
peripheral blood	11 studies	29% ± 8%	Explore
liver	4 studies	17% ± 1%	Explore
bone marrow	3 studies	30% ± 10%	Explore
brain	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	5171.94	578 / 578	100%	55.20	1150 / 1155
thymus	100%	2059.18	653 / 653	96%	33.82	579 / 605
stomach	97%	1176.42	347 / 359	99%	45.60	283 / 286
breast	100%	1703.00	459 / 459	93%	20.96	1043 / 1118
prostate	97%	1112.80	237 / 245	96%	16.52	480 / 502
bladder	100%	1398.76	21 / 21	91%	30.63	459 / 504
pancreas	94%	1005.79	307 / 328	97%	32.10	173 / 178
intestine	91%	1526.70	876 / 966	99%	39.00	520 / 527
esophagus	87%	904.29	1256 / 1445	99%	39.29	181 / 183
liver	96%	1091.98	218 / 226	87%	14.55	352 / 406
kidney	93%	973.53	83 / 89	89%	21.24	801 / 901
adrenal gland	97%	1248.93	250 / 258	79%	31.77	182 / 230
uterus	76%	571.49	129 / 170	94%	29.10	433 / 459
brain	65%	694.37	1729 / 2642	90%	19.49	637 / 705
skin	70%	494.71	1268 / 1809	78%	16.95	367 / 472
ovary	48%	343.88	86 / 180	96%	22.95	412 / 430
adipose	100%	1822.85	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	116.38	29 / 29
peripheral blood	100%	25156.15	929 / 929	0%	0	0 / 0
spleen	100%	11922.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	47.29	43 / 45
blood vessel	91%	991.61	1210 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	65%	10.05	52 / 80
heart	63%	460.30	544 / 861	0%	0	0 / 0
muscle	3%	14.51	23 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002768	Biological process	immune response-regulating cell surface receptor signaling pathway
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0034136	Biological process	negative regulation of toll-like receptor 2 signaling pathway
GO_1902961	Biological process	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO_0060369	Biological process	positive regulation of Fc receptor mediated stimulatory signaling pathway
GO_2000670	Biological process	positive regulation of dendritic cell apoptotic process
GO_0050777	Biological process	negative regulation of immune response
GO_0002902	Biological process	regulation of B cell apoptotic process
GO_0002862	Biological process	negative regulation of inflammatory response to antigenic stimulus
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0050900	Biological process	leukocyte migration
GO_0033628	Biological process	regulation of cell adhesion mediated by integrin
GO_0034142	Biological process	toll-like receptor 4 signaling pathway
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0006468	Biological process	protein phosphorylation
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0070668	Biological process	positive regulation of mast cell proliferation
GO_0030889	Biological process	negative regulation of B cell proliferation
GO_0002774	Biological process	Fc receptor mediated inhibitory signaling pathway
GO_0071300	Biological process	cellular response to retinoic acid
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0043200	Biological process	response to amino acid
GO_0038043	Biological process	interleukin-5-mediated signaling pathway
GO_0060252	Biological process	positive regulation of glial cell proliferation
GO_0045087	Biological process	innate immune response
GO_0031175	Biological process	neuron projection development
GO_0007165	Biological process	signal transduction
GO_0031295	Biological process	T cell costimulation
GO_0002576	Biological process	platelet degranulation
GO_0002553	Biological process	histamine secretion by mast cell
GO_0009725	Biological process	response to hormone
GO_0045646	Biological process	regulation of erythrocyte differentiation
GO_0006991	Biological process	response to sterol depletion
GO_0009743	Biological process	response to carbohydrate
GO_0051279	Biological process	regulation of release of sequestered calcium ion into cytosol
GO_0046777	Biological process	protein autophosphorylation
GO_0000077	Biological process	DNA damage checkpoint signaling
GO_0033003	Biological process	regulation of mast cell activation
GO_0070447	Biological process	positive regulation of oligodendrocyte progenitor proliferation
GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0002431	Biological process	Fc receptor mediated stimulatory signaling pathway
GO_0014003	Biological process	oligodendrocyte development
GO_0060397	Biological process	growth hormone receptor signaling pathway via JAK-STAT
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0070667	Biological process	negative regulation of mast cell proliferation
GO_0001782	Biological process	B cell homeostasis
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0097028	Biological process	dendritic cell differentiation
GO_0002223	Biological process	stimulatory C-type lectin receptor signaling pathway
GO_0002762	Biological process	negative regulation of myeloid leukocyte differentiation
GO_0002513	Biological process	tolerance induction to self antigen
GO_0090025	Biological process	regulation of monocyte chemotaxis
GO_0050855	Biological process	regulation of B cell receptor signaling pathway
GO_0001817	Biological process	regulation of cytokine production
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0038159	Biological process	C-X-C chemokine receptor CXCR4 signaling pathway
GO_0009636	Biological process	response to toxic substance
GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0034605	Biological process	cellular response to heat
GO_0048678	Biological process	response to axon injury
GO_0043304	Biological process	regulation of mast cell degranulation
GO_0006974	Biological process	DNA damage response
GO_0032868	Biological process	response to insulin
GO_0014070	Biological process	response to organic cyclic compound
GO_0034144	Biological process	negative regulation of toll-like receptor 4 signaling pathway
GO_0030222	Biological process	eosinophil differentiation
GO_0038095	Biological process	Fc-epsilon receptor signaling pathway
GO_0001932	Biological process	regulation of protein phosphorylation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0090330	Biological process	regulation of platelet aggregation
GO_0002250	Biological process	adaptive immune response
GO_0015908	Biological process	fatty acid transport
GO_0030218	Biological process	erythrocyte differentiation
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0030335	Biological process	positive regulation of cell migration
GO_1902532	Biological process	negative regulation of intracellular signal transduction
GO_0038096	Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis
GO_0098978	Cellular component	glutamatergic synapse
GO_0045121	Cellular component	membrane raft
GO_0030061	Cellular component	mitochondrial crista
GO_0034666	Cellular component	integrin alpha2-beta1 complex
GO_0005634	Cellular component	nucleus
GO_0070062	Cellular component	extracellular exosome
GO_0005912	Cellular component	adherens junction
GO_0099091	Cellular component	postsynaptic specialization, intracellular component
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005886	Cellular component	plasma membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005737	Cellular component	cytoplasm
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005829	Cellular component	cytosol
GO_0005765	Cellular component	lysosomal membrane
GO_0043015	Molecular function	gamma-tubulin binding
GO_0141038	Molecular function	phosphatidylinositol 3-kinase activator activity
GO_0046875	Molecular function	ephrin receptor binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0097110	Molecular function	scaffold protein binding
GO_0005524	Molecular function	ATP binding
GO_0005102	Molecular function	signaling receptor binding
GO_0140031	Molecular function	phosphorylation-dependent protein binding
GO_0017124	Molecular function	SH3 domain binding
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0043208	Molecular function	glycosphingolipid binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0005161	Molecular function	platelet-derived growth factor receptor binding
GO_0005178	Molecular function	integrin binding
GO_0016301	Molecular function	kinase activity
GO_0051219	Molecular function	phosphoprotein binding

IV. Literature review

[source]

Gene name	LYN
Protein name	LYN proto-oncogene, Src family tyrosine kinase Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) Tyrosine-protein kinase (EC 2.7.10.2)
Synonyms	JTK8
Description	FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration . Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 . .
Accessions	ENST00000520220.6 [P07948-2] Q6NUK7 ENST00000519728.6 [P07948-1] ENST00000520050.1 P07948 E5RJ37

LYN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review