SLC12A3 | OmnibusX

Name	Number of supported studies	Average coverage
kidney distal convoluted tubule epithelial cell	5 studies	84% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC12A3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	21593.52	89 / 89	11%	9.84	97 / 901
spleen	100%	122.09	241 / 241	0%	0	0 / 0
pancreas	98%	21.75	320 / 328	2%	0.10	3 / 178
prostate	88%	18.01	215 / 245	7%	0.13	36 / 502
stomach	81%	22.14	290 / 359	2%	0.03	7 / 286
lung	78%	9.04	452 / 578	2%	0.25	20 / 1155
brain	76%	10.13	2001 / 2642	0%	0.01	1 / 705
lymph node	0%	0	0 / 0	76%	3.98	22 / 29
ovary	71%	5.98	128 / 180	4%	0.09	17 / 430
thymus	70%	9.43	458 / 653	1%	0.02	7 / 605
peripheral blood	70%	28.01	653 / 929	0%	0	0 / 0
bladder	62%	10.81	13 / 21	3%	0.80	15 / 504
intestine	63%	21.40	612 / 966	1%	0.02	6 / 527
breast	58%	5.41	264 / 459	4%	0.19	44 / 1118
skin	37%	2.32	662 / 1809	3%	0.04	12 / 472
adipose	39%	3.36	470 / 1204	0%	0	0 / 0
liver	38%	2.12	86 / 226	1%	0.01	3 / 406
uterus	35%	2.69	59 / 170	3%	0.42	13 / 459
esophagus	36%	3.29	526 / 1445	1%	0.02	2 / 183
adrenal gland	35%	2.20	91 / 258	0%	0	0 / 230
blood vessel	32%	2.45	422 / 1335	0%	0	0 / 0
muscle	26%	1.26	207 / 803	0%	0	0 / 0
heart	18%	0.95	151 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0070294	Biological process	renal sodium ion absorption
GO_0055064	Biological process	chloride ion homeostasis
GO_0007165	Biological process	signal transduction
GO_0055078	Biological process	sodium ion homeostasis
GO_0006811	Biological process	monoatomic ion transport
GO_0006884	Biological process	cell volume homeostasis
GO_0055075	Biological process	potassium ion homeostasis
GO_0002021	Biological process	response to dietary excess
GO_1902476	Biological process	chloride transmembrane transport
GO_0006814	Biological process	sodium ion transport
GO_1904044	Biological process	response to aldosterone
GO_0035725	Biological process	sodium ion transmembrane transport
GO_1990573	Biological process	potassium ion import across plasma membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0015378	Molecular function	sodium:chloride symporter activity
GO_0008511	Molecular function	sodium:potassium:chloride symporter activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	SLC12A3
Protein name	Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) Alternative protein SLC12A3 Solute carrier family 12 member 3
Synonyms	TSC NCC
Description	FUNCTION: Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules . Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). .
Accessions	J3QSS1 ENST00000262502.5 L8E783 ENST00000566786.5 [P55017-3] ENST00000438926.6 [P55017-2] ENST00000563236.6 [P55017-1] P55017

SLC12A3 report