ARHGAP44 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0035021Biological processnegative regulation of Rac protein signal transduction
GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0098886Biological processmodification of dendritic spine
GO_0098887Biological processneurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_0006887Biological processexocytosis
GO_0043087Biological processregulation of GTPase activity
GO_0051490Biological processnegative regulation of filopodium assembly
GO_0099152Biological processregulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0098978Cellular componentglutamatergic synapse
GO_0005622Cellular componentintracellular anatomical structure
GO_0031256Cellular componentleading edge membrane
GO_0043197Cellular componentdendritic spine
GO_0055037Cellular componentrecycling endosome
GO_0030425Cellular componentdendrite
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005543Molecular functionphospholipid binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARHGAP44
Protein nameARHGAP44
Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)
Rho GTPase activating protein 44
SynonymsKIAA0672
RICH2
DescriptionFUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 . In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). .

AccessionsENST00000580768.5
ENST00000379672.10 [Q17R89-1]
ENST00000340825.7 [Q17R89-3]
E7ERK8
ENST00000544416.6
J3KRS3
J3QQU7
ENST00000583608.1
ENST00000581437.1
Q17R89
K7EK86
A0A2X0U4K4
F5H6L3
ENST00000262444.13