Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 13 studies | 53% ± 25% | |
GABAergic neuron | 10 studies | 48% ± 28% | |
type I pneumocyte | 8 studies | 45% ± 21% | |
pericyte | 7 studies | 28% ± 10% | |
retina horizontal cell | 6 studies | 57% ± 28% | |
type II pneumocyte | 6 studies | 33% ± 11% | |
endothelial cell | 5 studies | 33% ± 13% | |
retinal ganglion cell | 5 studies | 42% ± 12% | |
amacrine cell | 5 studies | 45% ± 18% | |
ciliated cell | 5 studies | 31% ± 14% | |
interneuron | 5 studies | 56% ± 27% | |
granule cell | 4 studies | 46% ± 22% | |
mesothelial cell | 4 studies | 47% ± 19% | |
oligodendrocyte precursor cell | 4 studies | 24% ± 9% | |
epithelial cell | 4 studies | 28% ± 8% | |
club cell | 4 studies | 24% ± 4% | |
neuron | 3 studies | 33% ± 3% | |
GABAergic interneuron | 3 studies | 42% ± 8% | |
GABAergic amacrine cell | 3 studies | 54% ± 8% | |
glycinergic amacrine cell | 3 studies | 55% ± 5% | |
astrocyte | 3 studies | 32% ± 17% | |
fibroblast | 3 studies | 21% ± 2% | |
transit amplifying cell | 3 studies | 23% ± 7% | |
smooth muscle cell | 3 studies | 22% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 99% | 930.95 | 243 / 245 | 99% | 4.64 | 498 / 502 |
thymus | 100% | 1720.59 | 652 / 653 | 95% | 9.70 | 576 / 605 |
stomach | 99% | 659.22 | 354 / 359 | 94% | 6.47 | 269 / 286 |
intestine | 97% | 1249.46 | 941 / 966 | 91% | 4.78 | 477 / 527 |
ovary | 100% | 1175.89 | 180 / 180 | 87% | 4.06 | 376 / 430 |
lung | 99% | 1762.07 | 575 / 578 | 83% | 4.60 | 954 / 1155 |
brain | 96% | 3132.68 | 2546 / 2642 | 81% | 4.46 | 570 / 705 |
kidney | 93% | 580.09 | 83 / 89 | 81% | 3.36 | 729 / 901 |
pancreas | 83% | 410.07 | 273 / 328 | 90% | 4.02 | 161 / 178 |
breast | 93% | 641.73 | 427 / 459 | 80% | 3.03 | 895 / 1118 |
bladder | 95% | 645.81 | 20 / 21 | 61% | 2.42 | 306 / 504 |
uterus | 99% | 1253.35 | 168 / 170 | 49% | 1.76 | 225 / 459 |
esophagus | 67% | 460.96 | 970 / 1445 | 68% | 3.79 | 125 / 183 |
adrenal gland | 31% | 137.21 | 80 / 258 | 73% | 6.01 | 167 / 230 |
blood vessel | 98% | 888.08 | 1313 / 1335 | 0% | 0 | 0 / 0 |
adipose | 92% | 861.20 | 1105 / 1204 | 0% | 0 | 0 / 0 |
heart | 89% | 599.00 | 763 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 83% | 4.94 | 24 / 29 |
skin | 49% | 230.03 | 890 / 1809 | 9% | 0.19 | 43 / 472 |
muscle | 45% | 175.73 | 358 / 803 | 0% | 0 | 0 / 0 |
liver | 1% | 4.92 | 3 / 226 | 29% | 1.15 | 117 / 406 |
tonsil | 0% | 0 | 0 / 0 | 11% | 0.27 | 5 / 45 |
spleen | 11% | 39.58 | 26 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 9% | 73.50 | 87 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 9% | 0.26 | 7 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0050804 | Biological process | modulation of chemical synaptic transmission |
GO_0035021 | Biological process | negative regulation of Rac protein signal transduction |
GO_0007165 | Biological process | signal transduction |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0098886 | Biological process | modification of dendritic spine |
GO_0098887 | Biological process | neurotransmitter receptor transport, endosome to postsynaptic membrane |
GO_0061001 | Biological process | regulation of dendritic spine morphogenesis |
GO_0006887 | Biological process | exocytosis |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_0051490 | Biological process | negative regulation of filopodium assembly |
GO_0099152 | Biological process | regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005622 | Cellular component | intracellular anatomical structure |
GO_0031256 | Cellular component | leading edge membrane |
GO_0043197 | Cellular component | dendritic spine |
GO_0055037 | Cellular component | recycling endosome |
GO_0030425 | Cellular component | dendrite |
GO_0048786 | Cellular component | presynaptic active zone |
GO_0005829 | Cellular component | cytosol |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005543 | Molecular function | phospholipid binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ARHGAP44 |
Protein name | ARHGAP44 Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) Rho GTPase activating protein 44 |
Synonyms | KIAA0672 RICH2 |
Description | FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 . In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). . |
Accessions | ENST00000580768.5 ENST00000379672.10 [Q17R89-1] ENST00000340825.7 [Q17R89-3] E7ERK8 ENST00000544416.6 J3KRS3 J3QQU7 ENST00000583608.1 ENST00000581437.1 Q17R89 K7EK86 A0A2X0U4K4 F5H6L3 ENST00000262444.13 |