I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| dendritic cell | 3 studies | 19% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| dendritic cell | 3 studies | 19% ± 3% |
Insufficient scRNA-seq data for expression of TNFSF9 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 87% | 92.77 | 1579 / 1809 | 93% | 14.91 | 441 / 472 |
| lung | 98% | 375.18 | 568 / 578 | 80% | 11.91 | 928 / 1155 |
| kidney | 65% | 64.93 | 58 / 89 | 87% | 18.50 | 786 / 901 |
| esophagus | 68% | 268.11 | 987 / 1445 | 81% | 14.61 | 149 / 183 |
| intestine | 66% | 69.71 | 638 / 966 | 78% | 18.18 | 409 / 527 |
| brain | 97% | 193.55 | 2553 / 2642 | 30% | 1.99 | 215 / 705 |
| uterus | 31% | 46.65 | 52 / 170 | 73% | 18.80 | 335 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 33.68 | 29 / 29 |
| spleen | 98% | 178.71 | 237 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 18.04 | 77 / 80 |
| stomach | 28% | 28.99 | 99 / 359 | 69% | 13.20 | 196 / 286 |
| adrenal gland | 66% | 40.33 | 170 / 258 | 28% | 4.14 | 65 / 230 |
| adipose | 89% | 133.63 | 1071 / 1204 | 0% | 0 | 0 / 0 |
| breast | 60% | 61.50 | 275 / 459 | 27% | 1.71 | 305 / 1118 |
| bladder | 29% | 17.71 | 6 / 21 | 56% | 11.03 | 281 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 14.37 | 36 / 45 |
| pancreas | 2% | 0.60 | 5 / 328 | 76% | 12.03 | 136 / 178 |
| thymus | 34% | 27.94 | 219 / 653 | 35% | 4.14 | 210 / 605 |
| peripheral blood | 61% | 1404.42 | 567 / 929 | 0% | 0 | 0 / 0 |
| ovary | 28% | 32.64 | 50 / 180 | 28% | 2.76 | 122 / 430 |
| blood vessel | 39% | 37.23 | 517 / 1335 | 0% | 0 | 0 / 0 |
| liver | 15% | 10.79 | 35 / 226 | 19% | 1.27 | 79 / 406 |
| muscle | 31% | 22.26 | 245 / 803 | 0% | 0 | 0 / 0 |
| prostate | 18% | 9.66 | 45 / 245 | 10% | 0.57 | 51 / 502 |
| heart | 22% | 19.22 | 192 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0006955 | Biological process | immune response |
| GO_0042129 | Biological process | regulation of T cell proliferation |
| GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0045585 | Biological process | positive regulation of cytotoxic T cell differentiation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
| GO_0032813 | Molecular function | tumor necrosis factor receptor superfamily binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | TNFSF9 |
| Protein name | Tumor necrosis factor (Ligand) superfamily, member 9, isoform CRA_a (Tumor necrosis factor ligand 5A) Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL) |
| Synonyms | TNLG5A hCG_23042 |
| Description | FUNCTION: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. . |
| Accessions | A0A0U5J8I0 P41273 ENST00000245817.5 |
