TRAF2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRAF2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRAF2 at tissue level.

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0046328Biological processregulation of JNK cascade
GO_0002726Biological processpositive regulation of T cell cytokine production
GO_1903265Biological processpositive regulation of tumor necrosis factor-mediated signaling pathway
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0051865Biological processprotein autoubiquitination
GO_0048255Biological processmRNA stabilization
GO_0002637Biological processregulation of immunoglobulin production
GO_0071732Biological processcellular response to nitric oxide
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0065003Biological processprotein-containing complex assembly
GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0042981Biological processregulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0097300Biological processprogrammed necrotic cell death
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0030163Biological processprotein catabolic process
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0034351Biological processnegative regulation of glial cell apoptotic process
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0097400Biological processinterleukin-17-mediated signaling pathway
GO_0002947Cellular componenttumor necrosis factor receptor superfamily complex
GO_0000151Cellular componentubiquitin ligase complex
GO_1990604Cellular componentIRE1-TRAF2-ASK1 complex
GO_0045121Cellular componentmembrane raft
GO_0012506Cellular componentvesicle membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0098802Cellular componentplasma membrane signaling receptor complex
GO_0035631Cellular componentCD40 receptor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0097057Cellular componentTRAF2-GSTP1 complex
GO_0019899Molecular functionenzyme binding
GO_0043120Molecular functiontumor necrosis factor binding
GO_0031996Molecular functionthioesterase binding
GO_0046625Molecular functionsphingolipid binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005174Molecular functionCD40 receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAF2
Protein nameTNF receptor-associated factor (EC 2.3.2.27)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
TNF receptor associated factor 2
SynonymsTRAP3
DescriptionFUNCTION: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis . Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. .

AccessionsB1AMY1
ENST00000247668.7 [Q12933-1]
ENST00000414589.1
ENST00000429509.5
ENST00000419057.5
Q12933
B1AMX8
E5KBQ3
B1AMX7