Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 10 studies | 22% ± 7% | |
| type II pneumocyte | 6 studies | 36% ± 11% | |
| epithelial cell | 5 studies | 18% ± 3% | |
| adipocyte | 5 studies | 26% ± 7% | |
| myofibroblast cell | 3 studies | 20% ± 1% | |
| pericyte | 3 studies | 19% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| lung | 4 studies | 17% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 4570.19 | 1806 / 1809 | 100% | 34.95 | 471 / 472 |
| esophagus | 100% | 6075.80 | 1445 / 1445 | 99% | 35.64 | 181 / 183 |
| uterus | 100% | 9509.06 | 170 / 170 | 98% | 39.64 | 452 / 459 |
| thymus | 100% | 5814.14 | 653 / 653 | 98% | 42.25 | 595 / 605 |
| intestine | 100% | 4983.00 | 966 / 966 | 98% | 21.42 | 515 / 527 |
| lung | 100% | 5046.42 | 577 / 578 | 96% | 24.98 | 1114 / 1155 |
| ovary | 100% | 4799.03 | 180 / 180 | 95% | 24.40 | 410 / 430 |
| breast | 100% | 6261.66 | 459 / 459 | 94% | 21.00 | 1046 / 1118 |
| bladder | 100% | 5661.57 | 21 / 21 | 93% | 23.65 | 469 / 504 |
| kidney | 99% | 3330.93 | 88 / 89 | 89% | 26.36 | 798 / 901 |
| liver | 100% | 3433.12 | 226 / 226 | 84% | 13.91 | 342 / 406 |
| adrenal gland | 100% | 7725.52 | 258 / 258 | 80% | 18.03 | 185 / 230 |
| prostate | 100% | 6992.18 | 245 / 245 | 77% | 7.95 | 388 / 502 |
| stomach | 78% | 2353.41 | 279 / 359 | 99% | 22.25 | 282 / 286 |
| pancreas | 63% | 894.23 | 207 / 328 | 97% | 36.67 | 173 / 178 |
| brain | 60% | 1241.15 | 1576 / 2642 | 96% | 20.71 | 680 / 705 |
| adipose | 100% | 7423.48 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 35.72 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 19.80 | 1 / 1 |
| blood vessel | 100% | 6938.05 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 99% | 3435.79 | 239 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 26.75 | 79 / 80 |
| heart | 96% | 2439.10 | 829 / 861 | 0% | 0 | 0 / 0 |
| muscle | 67% | 1178.30 | 538 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 6.98 | 14 / 29 |
| peripheral blood | 1% | 7.24 | 6 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0016485 | Biological process | protein processing |
| GO_0009953 | Biological process | dorsal/ventral pattern formation |
| GO_0030154 | Biological process | cell differentiation |
| GO_0006508 | Biological process | proteolysis |
| GO_0001501 | Biological process | skeletal system development |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0001503 | Biological process | ossification |
| GO_0001502 | Biological process | cartilage condensation |
| GO_0061036 | Biological process | positive regulation of cartilage development |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031982 | Cellular component | vesicle |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0008233 | Molecular function | peptidase activity |
| GO_0008237 | Molecular function | metallopeptidase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | BMP1 |
| Protein name | Metalloendopeptidase (EC 3.4.24.-) Bone morphogenetic protein 1 Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) BMP1 protein (Bone morphogenetic protein 1) |
| Synonyms | PCOLC |
| Description | FUNCTION: Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins . Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair . Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers . Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation . .; FUNCTION: [Isoform BMP1-3]: Plays an important role in bone repair by acting as a coactivator of BMP7. . |
| Accessions | E5RH22 ENST00000306385.10 [P13497-1] ENST00000520970.5 [P13497-2] P13497 ENST00000471755.5 [P13497-4] ENST00000518913.5 A5PLK9 ENST00000520626.6 ENST00000483364.5 ENST00000354870.5 ENST00000520982.5 ENST00000521385.5 [P13497-5] ENST00000306349.13 [P13497-2] Q3MIM8 B7ZKR5 ENST00000518656.5 ENST00000397814.7 |
