LRR1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRR1 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0016567Biological processprotein ubiquitination
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRR1
Protein nameLeucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)
Leucine rich repeat protein 1 (Peptidylprolyl isomerase (Cyclophilin)-like 5, isoform CRA_d)
Leucine rich repeat protein 1 (PPIL5 protein)
SynonymshCG_1640043
PPIL5
DescriptionFUNCTION: Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 . .

AccessionsENST00000554869.5
Q6P393
ENST00000298288.11 [Q96L50-1]
Q96L50
ENST00000540712.1
ENST00000318317.8 [Q96L50-2]
G3V5H2