CD320 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0016192Biological processvesicle-mediated transport
GO_0031296Biological processB cell costimulation
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0030656Biological processregulation of vitamin metabolic process
GO_0021517Biological processventral spinal cord development
GO_0015889Biological processcobalamin transport
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0005901Cellular componentcaveola
GO_0016020Cellular componentmembrane
GO_0031419Molecular functioncobalamin binding
GO_0008083Molecular functiongrowth factor activity
GO_0038024Molecular functioncargo receptor activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD320
Protein nameCD320 molecule
CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320)
Synonyms8D6A
UNQ198/PRO224
DescriptionFUNCTION: Receptor for transcobalamin saturated with cobalamin (TCbl) . Plays an important role in cobalamin uptake . Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells . Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation . Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) . CD320 augments the proliferation of PC precursors generated by IL-10 . .

AccessionsENST00000301458.10 [Q9NPF0-1]
ENST00000596002.5
ENST00000599573.1
Q9NPF0
ENST00000537716.6 [Q9NPF0-2]
M0R100
M0R1C4