OCRL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0001701Biological processin utero embryonic development
GO_0007165Biological processsignal transduction
GO_0061024Biological processmembrane organization
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0043647Biological processinositol phosphate metabolic process
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0005795Cellular componentGolgi stack
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0005798Cellular componentGolgi-associated vesicle
GO_0005634Cellular componentnucleus
GO_0052658Molecular functioninositol-1,4,5-trisphosphate 5-phosphatase activity
GO_0034485Molecular functionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO_0004439Molecular functionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0034596Molecular functionphosphatidylinositol phosphate 4-phosphatase activity
GO_0052659Molecular functioninositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO_0004445Molecular functioninositol-polyphosphate 5-phosphatase activity
GO_0052745Molecular functioninositol phosphate phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0043813Molecular functionphosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

IV. Literature review

[source]
Gene nameOCRL
Protein namephosphoinositide 5-phosphatase (EC 3.1.3.36)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
OCRL protein
OCRL inositol polyphosphate-5-phosphatase
SynonymsOCRL1
DescriptionFUNCTION: Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 . Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate . Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes . Involved in primary cilia assembly . Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling . .

AccessionsENST00000646010.1
A0A2R8YCN4
ENST00000646914.1
A0A2R8YG38
A0A2R8YF88
ENST00000647245.1
A0A8I5KYX7
ENST00000693473.1
A0A8I5KTM3
ENST00000689093.1
ENST00000691455.1
Q6PJ10
ENST00000371113.9 [Q01968-1]
Q504W7
ENST00000357121.5 [Q01968-2]
Q01968
A0A2X0TVZ9