YWHAH | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	41% ± 18%	Explore
macrophage	32 studies	41% ± 16%	Explore
fibroblast	27 studies	26% ± 12%	Explore
pericyte	27 studies	37% ± 18%	Explore
smooth muscle cell	24 studies	32% ± 8%	Explore
conventional dendritic cell	22 studies	40% ± 16%	Explore
B cell	21 studies	25% ± 9%	Explore
endothelial cell of lymphatic vessel	17 studies	55% ± 13%	Explore
T cell	16 studies	26% ± 8%	Explore
ciliated cell	16 studies	40% ± 19%	Explore
non-classical monocyte	15 studies	28% ± 11%	Explore
epithelial cell	15 studies	36% ± 20%	Explore
microglial cell	13 studies	44% ± 22%	Explore
regulatory T cell	13 studies	23% ± 4%	Explore
monocyte	12 studies	30% ± 14%	Explore
natural killer cell	12 studies	26% ± 9%	Explore
capillary endothelial cell	12 studies	41% ± 7%	Explore
dendritic cell	11 studies	45% ± 18%	Explore
platelet	11 studies	49% ± 20%	Explore
classical monocyte	11 studies	27% ± 12%	Explore
endothelial cell of artery	11 studies	35% ± 15%	Explore
glutamatergic neuron	11 studies	51% ± 20%	Explore
connective tissue cell	11 studies	33% ± 13%	Explore
endothelial cell of vascular tree	11 studies	39% ± 12%	Explore
myeloid cell	11 studies	39% ± 17%	Explore
myofibroblast cell	10 studies	27% ± 11%	Explore
vein endothelial cell	10 studies	32% ± 9%	Explore
basal cell	10 studies	39% ± 16%	Explore
CD4-positive, alpha-beta T cell	9 studies	20% ± 3%	Explore
neuron	8 studies	56% ± 21%	Explore
GABAergic neuron	8 studies	36% ± 16%	Explore
CD8-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
type I pneumocyte	7 studies	34% ± 13%	Explore
leukocyte	7 studies	36% ± 13%	Explore
gamma-delta T cell	7 studies	26% ± 12%	Explore
astrocyte	7 studies	25% ± 11%	Explore
innate lymphoid cell	7 studies	26% ± 6%	Explore
memory B cell	7 studies	23% ± 8%	Explore
secretory cell	7 studies	31% ± 14%	Explore
alveolar macrophage	6 studies	44% ± 13%	Explore
hematopoietic precursor cell	6 studies	30% ± 15%	Explore
retinal ganglion cell	6 studies	74% ± 30%	Explore
oligodendrocyte	6 studies	20% ± 5%	Explore
plasmablast	5 studies	41% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	22% ± 5%	Explore
mononuclear phagocyte	5 studies	41% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	24% ± 5%	Explore
mature NK T cell	5 studies	20% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 3%	Explore
goblet cell	5 studies	31% ± 17%	Explore
transit amplifying cell	5 studies	25% ± 4%	Explore
abnormal cell	5 studies	31% ± 6%	Explore
interneuron	5 studies	41% ± 16%	Explore
deuterosomal cell	4 studies	54% ± 14%	Explore
ionocyte	4 studies	31% ± 8%	Explore
pancreatic A cell	4 studies	55% ± 22%	Explore
type B pancreatic cell	4 studies	51% ± 21%	Explore
naive B cell	4 studies	16% ± 1%	Explore
progenitor cell	4 studies	20% ± 5%	Explore
retinal cone cell	4 studies	27% ± 9%	Explore
megakaryocyte	4 studies	45% ± 24%	Explore
plasma cell	4 studies	26% ± 13%	Explore
pro-B cell	4 studies	26% ± 7%	Explore
amacrine cell	4 studies	58% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	37% ± 11%	Explore
oligodendrocyte precursor cell	4 studies	21% ± 5%	Explore
erythrocyte	4 studies	44% ± 17%	Explore
mucosal invariant T cell	4 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	21% ± 2%	Explore
club cell	3 studies	22% ± 4%	Explore
squamous epithelial cell	3 studies	37% ± 30%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
glomerular endothelial cell	3 studies	28% ± 2%	Explore
neural crest cell	3 studies	36% ± 13%	Explore
OFF-bipolar cell	3 studies	53% ± 34%	Explore
ON-bipolar cell	3 studies	53% ± 34%	Explore
GABAergic amacrine cell	3 studies	45% ± 18%	Explore
retinal rod cell	3 studies	29% ± 7%	Explore
lymphocyte	3 studies	39% ± 11%	Explore
retina horizontal cell	3 studies	43% ± 14%	Explore
adventitial cell	3 studies	24% ± 11%	Explore
Mueller cell	3 studies	28% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 1%	Explore
mesothelial cell	3 studies	30% ± 18%	Explore
luminal cell of prostate epithelium	3 studies	32% ± 7%	Explore
pancreatic ductal cell	3 studies	41% ± 10%	Explore
enteroendocrine cell	3 studies	43% ± 13%	Explore
glial cell	3 studies	34% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 8%	Explore
T-helper 17 cell	3 studies	30% ± 10%	Explore
erythroblast	3 studies	46% ± 31%	Explore
progenitor cell of mammary luminal epithelium	3 studies	39% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	29% ± 9%	Explore
brain	13 studies	39% ± 19%	Explore
intestine	9 studies	27% ± 13%	Explore
peripheral blood	6 studies	28% ± 11%	Explore
eye	6 studies	32% ± 11%	Explore
pancreas	4 studies	50% ± 23%	Explore
kidney	4 studies	26% ± 9%	Explore
uterus	4 studies	32% ± 11%	Explore
lymph node	4 studies	28% ± 16%	Explore
breast	4 studies	32% ± 10%	Explore
placenta	3 studies	22% ± 6%	Explore
prostate	3 studies	31% ± 7%	Explore
liver	3 studies	41% ± 33%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	7650.71	966 / 966	100%	208.52	527 / 527
breast	100%	6978.11	459 / 459	100%	251.37	1117 / 1118
lung	100%	9754.43	577 / 578	100%	197.23	1155 / 1155
skin	99%	5677.74	1792 / 1809	100%	181.18	471 / 472
esophagus	99%	7594.53	1428 / 1445	100%	185.28	183 / 183
uterus	99%	6059.49	168 / 170	100%	220.79	459 / 459
brain	99%	26239.84	2610 / 2642	100%	288.14	705 / 705
thymus	98%	5928.68	643 / 653	100%	134.22	603 / 605
kidney	98%	5801.28	87 / 89	100%	236.98	900 / 901
bladder	95%	7068.33	20 / 21	99%	181.66	501 / 504
prostate	96%	5491.80	235 / 245	99%	97.66	495 / 502
ovary	94%	4308.66	169 / 180	100%	155.17	430 / 430
stomach	94%	5370.21	337 / 359	100%	209.32	286 / 286
adrenal gland	91%	4145.81	235 / 258	96%	252.33	221 / 230
pancreas	79%	3287.56	260 / 328	99%	237.13	177 / 178
liver	62%	2184.06	139 / 226	98%	109.24	397 / 406
blood vessel	100%	18610.09	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	166.06	29 / 29
spleen	100%	5263.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	200.43	45 / 45
ureter	0%	0	0 / 0	100%	70.28	1 / 1
adipose	100%	9012.88	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	118.14	79 / 80
heart	92%	4401.58	792 / 861	0%	0	0 / 0
peripheral blood	87%	4632.41	804 / 929	0%	0	0 / 0
muscle	80%	3012.12	642 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045664	Biological process	regulation of neuron differentiation
GO_2000649	Biological process	regulation of sodium ion transmembrane transporter activity
GO_0002028	Biological process	regulation of sodium ion transport
GO_0007165	Biological process	signal transduction
GO_0006886	Biological process	intracellular protein transport
GO_0006713	Biological process	glucocorticoid catabolic process
GO_0042921	Biological process	nuclear receptor-mediated glucocorticoid signaling pathway
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0099171	Biological process	presynaptic modulation of chemical synaptic transmission
GO_0021762	Biological process	substantia nigra development
GO_0086010	Biological process	membrane depolarization during action potential
GO_0008104	Biological process	protein localization
GO_0050774	Biological process	negative regulation of dendrite morphogenesis
GO_0098793	Cellular component	presynapse
GO_0005886	Cellular component	plasma membrane
GO_0150048	Cellular component	cerebellar granule cell to Purkinje cell synapse
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0014704	Cellular component	intercalated disc
GO_0019899	Molecular function	enzyme binding
GO_0035259	Molecular function	nuclear glucocorticoid receptor binding
GO_0005159	Molecular function	insulin-like growth factor receptor binding
GO_0019904	Molecular function	protein domain specific binding
GO_0042802	Molecular function	identical protein binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0017080	Molecular function	sodium channel regulator activity
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	YWHAH
Protein name	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 14-3-3 protein eta (Protein AS1)
Synonyms	YWHA1
Description	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. .
Accessions	A2IDB1 Q04917 ENST00000443669.5 F8WEB6 A2IDB2 ENST00000397492.1 ENST00000420430.1 ENST00000248975.6

YWHAH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review