LRPAP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	31 studies	36% ± 14%	Explore
macrophage	28 studies	34% ± 16%	Explore
natural killer cell	27 studies	26% ± 7%	Explore
endothelial cell	24 studies	27% ± 11%	Explore
pericyte	22 studies	30% ± 11%	Explore
classical monocyte	22 studies	33% ± 14%	Explore
smooth muscle cell	21 studies	29% ± 10%	Explore
non-classical monocyte	21 studies	34% ± 15%	Explore
regulatory T cell	19 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	18 studies	23% ± 7%	Explore
T cell	17 studies	21% ± 6%	Explore
monocyte	17 studies	30% ± 12%	Explore
basal cell	17 studies	31% ± 17%	Explore
connective tissue cell	17 studies	31% ± 12%	Explore
CD4-positive, alpha-beta T cell	16 studies	21% ± 6%	Explore
B cell	15 studies	23% ± 6%	Explore
plasma cell	15 studies	46% ± 16%	Explore
endothelial cell of lymphatic vessel	15 studies	37% ± 10%	Explore
conventional dendritic cell	14 studies	31% ± 15%	Explore
epithelial cell	14 studies	34% ± 21%	Explore
ciliated cell	13 studies	44% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	28% ± 8%	Explore
myofibroblast cell	12 studies	31% ± 11%	Explore
gamma-delta T cell	12 studies	25% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	22% ± 5%	Explore
mature NK T cell	11 studies	25% ± 6%	Explore
mast cell	10 studies	20% ± 4%	Explore
plasmablast	10 studies	45% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	26% ± 6%	Explore
endothelial cell of artery	10 studies	21% ± 5%	Explore
myeloid cell	10 studies	32% ± 16%	Explore
naive B cell	9 studies	19% ± 3%	Explore
capillary endothelial cell	9 studies	21% ± 3%	Explore
mucosal invariant T cell	9 studies	22% ± 4%	Explore
memory B cell	9 studies	20% ± 4%	Explore
alveolar macrophage	8 studies	50% ± 22%	Explore
type I pneumocyte	8 studies	30% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 5%	Explore
secretory cell	8 studies	29% ± 13%	Explore
abnormal cell	8 studies	26% ± 5%	Explore
dendritic cell	8 studies	33% ± 20%	Explore
astrocyte	8 studies	27% ± 15%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	20% ± 4%	Explore
leukocyte	6 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	30% ± 7%	Explore
epithelial cell of proximal tubule	6 studies	30% ± 9%	Explore
neuron	6 studies	23% ± 9%	Explore
enterocyte	6 studies	19% ± 3%	Explore
mesothelial cell	6 studies	33% ± 17%	Explore
innate lymphoid cell	6 studies	23% ± 4%	Explore
type II pneumocyte	6 studies	28% ± 12%	Explore
T follicular helper cell	6 studies	19% ± 3%	Explore
endothelial cell of vascular tree	6 studies	25% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 2%	Explore
kidney loop of Henle epithelial cell	5 studies	28% ± 12%	Explore
vein endothelial cell	5 studies	20% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 11%	Explore
oligodendrocyte precursor cell	5 studies	31% ± 12%	Explore
pancreatic A cell	4 studies	70% ± 11%	Explore
type B pancreatic cell	4 studies	43% ± 16%	Explore
mononuclear phagocyte	4 studies	34% ± 14%	Explore
exhausted T cell	4 studies	27% ± 9%	Explore
hematopoietic precursor cell	4 studies	40% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	36% ± 6%	Explore
club cell	4 studies	34% ± 11%	Explore
microglial cell	4 studies	27% ± 6%	Explore
adventitial cell	4 studies	38% ± 12%	Explore
intermediate monocyte	4 studies	42% ± 14%	Explore
IgG plasma cell	4 studies	26% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 4%	Explore
enteroendocrine cell	4 studies	31% ± 17%	Explore
goblet cell	4 studies	32% ± 10%	Explore
duct epithelial cell	3 studies	25% ± 5%	Explore
respiratory goblet cell	3 studies	32% ± 17%	Explore
pancreatic D cell	3 studies	57% ± 13%	Explore
glomerular endothelial cell	3 studies	23% ± 6%	Explore
progenitor cell	3 studies	25% ± 7%	Explore
renal alpha-intercalated cell	3 studies	25% ± 6%	Explore
retinal bipolar neuron	3 studies	28% ± 9%	Explore
placental villous trophoblast	3 studies	84% ± 15%	Explore
common myeloid progenitor	3 studies	29% ± 7%	Explore
lymphocyte	3 studies	35% ± 12%	Explore
immature B cell	3 studies	20% ± 2%	Explore
retinal cone cell	3 studies	36% ± 9%	Explore
retinal rod cell	3 studies	24% ± 6%	Explore
serous secreting cell	3 studies	36% ± 11%	Explore
Mueller cell	3 studies	31% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
IgA plasma cell	3 studies	30% ± 7%	Explore
myoepithelial cell	3 studies	29% ± 4%	Explore
GABAergic neuron	3 studies	33% ± 12%	Explore
glutamatergic neuron	3 studies	41% ± 19%	Explore
pancreatic ductal cell	3 studies	58% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	48% ± 7%	Explore
neutrophil	3 studies	21% ± 6%	Explore
glial cell	3 studies	27% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 9%	Explore
T-helper 1 cell	3 studies	20% ± 2%	Explore
hematopoietic stem cell	3 studies	16% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	23% ± 7%	Explore
double negative thymocyte	3 studies	29% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	32% ± 12%	Explore
peripheral blood	14 studies	28% ± 8%	Explore
intestine	8 studies	23% ± 11%	Explore
kidney	7 studies	27% ± 4%	Explore
brain	7 studies	28% ± 11%	Explore
eye	5 studies	27% ± 8%	Explore
pancreas	4 studies	51% ± 16%	Explore
placenta	4 studies	40% ± 20%	Explore
uterus	4 studies	43% ± 15%	Explore
breast	4 studies	21% ± 2%	Explore
liver	4 studies	26% ± 8%	Explore
bone marrow	3 studies	22% ± 5%	Explore
lymph node	3 studies	28% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	7952.31	180 / 180	100%	33.01	430 / 430
pancreas	100%	5945.57	328 / 328	100%	42.20	178 / 178
thymus	100%	7604.05	653 / 653	100%	68.23	604 / 605
skin	100%	5448.99	1808 / 1809	100%	105.79	471 / 472
prostate	100%	6467.49	245 / 245	100%	53.39	500 / 502
lung	100%	7791.51	578 / 578	100%	37.24	1150 / 1155
liver	100%	4032.08	225 / 226	100%	36.09	406 / 406
brain	99%	7563.45	2628 / 2642	100%	40.77	705 / 705
kidney	100%	8248.60	89 / 89	99%	47.81	895 / 901
bladder	100%	6256.67	21 / 21	99%	43.56	499 / 504
stomach	100%	5995.23	359 / 359	99%	29.36	283 / 286
intestine	100%	6039.40	966 / 966	99%	33.87	521 / 527
uterus	100%	7645.64	170 / 170	99%	40.14	453 / 459
breast	100%	5823.73	459 / 459	98%	34.64	1101 / 1118
esophagus	100%	5276.46	1444 / 1445	98%	20.81	180 / 183
adrenal gland	100%	6659.16	258 / 258	98%	55.35	226 / 230
adipose	100%	5639.18	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	73.22	80 / 80
lymph node	0%	0	0 / 0	100%	30.87	29 / 29
spleen	100%	6961.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	33.24	45 / 45
ureter	0%	0	0 / 0	100%	23.54	1 / 1
blood vessel	100%	8502.31	1334 / 1335	0%	0	0 / 0
muscle	100%	4113.95	799 / 803	0%	0	0 / 0
peripheral blood	99%	10058.02	922 / 929	0%	0	0 / 0
heart	99%	10527.23	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0010916	Biological process	negative regulation of very-low-density lipoprotein particle clearance
GO_1900116	Biological process	extracellular negative regulation of signal transduction
GO_0048259	Biological process	regulation of receptor-mediated endocytosis
GO_0150093	Biological process	amyloid-beta clearance by transcytosis
GO_1900223	Biological process	positive regulation of amyloid-beta clearance
GO_0002091	Biological process	negative regulation of receptor internalization
GO_0032091	Biological process	negative regulation of protein binding
GO_1900222	Biological process	negative regulation of amyloid-beta clearance
GO_0005801	Cellular component	cis-Golgi network
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0012505	Cellular component	endomembrane system
GO_0005796	Cellular component	Golgi lumen
GO_0005794	Cellular component	Golgi apparatus
GO_0009986	Cellular component	cell surface
GO_0048237	Cellular component	rough endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0005768	Cellular component	endosome
GO_0031904	Cellular component	endosome lumen
GO_0008201	Molecular function	heparin binding
GO_0048018	Molecular function	receptor ligand activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0005102	Molecular function	signaling receptor binding
GO_0050750	Molecular function	low-density lipoprotein particle receptor binding
GO_0070326	Molecular function	very-low-density lipoprotein particle receptor binding
GO_0048019	Molecular function	receptor antagonist activity
GO_0005515	Molecular function	protein binding
GO_0035473	Molecular function	lipase binding

Gene name	LRPAP1
Protein name	LDL receptor related protein associated protein 1 Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)
Synonyms	A2MRAP
Description	FUNCTION: Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. .
Accessions	ENST00000650182.1 ENST00000515119.5 P30533 ENST00000648517.1 D6REW6 A0A3B3IRQ7

LRPAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review