MYO10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051489Biological processregulation of filopodium assembly
GO_0007165Biological processsignal transduction
GO_0008360Biological processregulation of cell shape
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0030705Biological processcytoskeleton-dependent intracellular transport
GO_0001726Cellular componentruffle
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0032433Cellular componentfilopodium tip
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0031527Cellular componentfilopodium membrane
GO_0030175Cellular componentfilopodium
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0030027Cellular componentlamellipodium
GO_0016459Cellular componentmyosin complex
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0030507Molecular functionspectrin binding
GO_0051015Molecular functionactin filament binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0005524Molecular functionATP binding
GO_0060002Molecular functionplus-end directed microfilament motor activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYO10
Protein nameMyosin X
MYO10 protein
Unconventional myosin-X (Unconventional myosin-10)
SynonymsKIAA0799
DescriptionFUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments . The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. .; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). .

AccessionsENST00000274203.13
Q9HD67
A0A0A0MQX1
E9PCN3
ENST00000502436.5
ENST00000515803.5
Q6IPD7
ENST00000505695.5
ENST00000513882.5
D6RGD1
E9PEW5
ENST00000507288.1 [Q9HD67-2]
ENST00000513610.6 [Q9HD67-1]