VLDLR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034436Biological processglycoprotein transport
GO_0034447Biological processvery-low-density lipoprotein particle clearance
GO_0006898Biological processreceptor-mediated endocytosis
GO_0048813Biological processdendrite morphogenesis
GO_0021517Biological processventral spinal cord development
GO_0007165Biological processsignal transduction
GO_0008203Biological processcholesterol metabolic process
GO_1900006Biological processpositive regulation of dendrite development
GO_0038026Biological processreelin-mediated signaling pathway
GO_0007613Biological processmemory
GO_0007399Biological processnervous system development
GO_0006869Biological processlipid transport
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0034361Cellular componentvery-low-density lipoprotein particle
GO_0005905Cellular componentclathrin-coated pit
GO_0005765Cellular componentlysosomal membrane
GO_0038025Molecular functionreelin receptor activity
GO_0038024Molecular functioncargo receptor activity
GO_0034185Molecular functionapolipoprotein binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0005041Molecular functionlow-density lipoprotein particle receptor activity
GO_0030229Molecular functionvery-low-density lipoprotein particle receptor activity
GO_0005509Molecular functioncalcium ion binding
GO_0034189Molecular functionvery-low-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVLDLR
Protein nameVery low-density lipoprotein receptor (VLDL receptor) (VLDL-R)
Very low density lipoprotein receptor
SynonymshCG_27927
DescriptionFUNCTION: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU . In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 . Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 . This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for Semliki Forest virus. .

AccessionsENST00000681942.1
A0A804CHQ2
A0A7P0TA42
ENST00000681806.1
Q5VVF8
ENST00000680296.1
Q5VVF5
A0A7P0T8C1
ENST00000382100.8 [P98155-1]
ENST00000382096.6
ENST00000680043.1
A0A7P0T897
A0A7P0T8F7
ENST00000681644.1
ENST00000680219.1
ENST00000681518.1
ENST00000680243.1
A0A7P0T8N6
A0A7P0Z477
A0A7P0TAL1
ENST00000382099.3
ENST00000680891.1
ENST00000681876.1
A0A7P0T9P7
A0A7P0TB10
ENST00000681306.1 [P98155-2]
P98155
ENST00000681618.1
A0A7P0T8N9
A0A7P0TBI2
ENST00000680746.1