RCVRN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007601Biological processvisual perception
GO_0007602Biological processphototransduction
GO_0051924Biological processregulation of calcium ion transport
GO_0043204Cellular componentperikaryon
GO_0001917Cellular componentphotoreceptor inner segment
GO_0001750Cellular componentphotoreceptor outer segment
GO_0016020Cellular componentmembrane
GO_0030425Cellular componentdendrite
GO_0005509Molecular functioncalcium ion binding
GO_0008048Molecular functioncalcium sensitive guanylate cyclase activator activity

IV. Literature review

[source]
Gene nameRCVRN
Protein nameRecoverin (Cancer-associated retinopathy protein) (Protein CAR)
SynonymsRCV1
DescriptionFUNCTION: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity). .

AccessionsP35243
ENST00000226193.6