Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD4-positive, alpha-beta T cell | 9 studies | 22% ± 3% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 8 studies | 22% ± 6% | |
| T follicular helper cell | 5 studies | 23% ± 4% | |
| T cell | 4 studies | 17% ± 2% | |
| CD4-positive, alpha-beta memory T cell | 3 studies | 18% ± 1% |
Insufficient scRNA-seq data for expression of TNFSF8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 221.03 | 575 / 578 | 80% | 3.78 | 928 / 1155 |
| breast | 90% | 73.59 | 414 / 459 | 88% | 3.83 | 983 / 1118 |
| stomach | 81% | 48.71 | 289 / 359 | 60% | 1.94 | 171 / 286 |
| thymus | 80% | 76.91 | 523 / 653 | 55% | 4.08 | 333 / 605 |
| intestine | 88% | 143.12 | 854 / 966 | 43% | 1.39 | 229 / 527 |
| kidney | 47% | 39.96 | 42 / 89 | 78% | 4.08 | 702 / 901 |
| prostate | 74% | 49.38 | 181 / 245 | 41% | 0.95 | 208 / 502 |
| bladder | 71% | 80.00 | 15 / 21 | 43% | 1.13 | 216 / 504 |
| esophagus | 62% | 33.06 | 895 / 1445 | 46% | 1.34 | 85 / 183 |
| skin | 43% | 20.46 | 776 / 1809 | 62% | 2.55 | 293 / 472 |
| pancreas | 30% | 12.45 | 100 / 328 | 73% | 3.56 | 130 / 178 |
| brain | 29% | 14.96 | 763 / 2642 | 75% | 2.92 | 526 / 705 |
| adrenal gland | 81% | 52.45 | 209 / 258 | 20% | 0.39 | 46 / 230 |
| spleen | 100% | 647.03 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 140.99 | 1186 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 35% | 17.57 | 63 / 180 | 63% | 2.73 | 271 / 430 |
| uterus | 56% | 27.26 | 95 / 170 | 42% | 0.95 | 191 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 13.74 | 27 / 29 |
| peripheral blood | 88% | 640.48 | 822 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 84% | 85.68 | 1126 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 2.25 | 31 / 45 |
| liver | 35% | 14.68 | 78 / 226 | 31% | 0.80 | 127 / 406 |
| heart | 38% | 19.15 | 327 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 10% | 0.19 | 8 / 80 |
| muscle | 7% | 2.32 | 55 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0006955 | Biological process | immune response |
| GO_0042129 | Biological process | regulation of T cell proliferation |
| GO_0043374 | Biological process | CD8-positive, alpha-beta T cell differentiation |
| GO_0050830 | Biological process | defense response to Gram-positive bacterium |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | TNFSF8 |
| Protein name | TNF superfamily member 8 Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153) Tumor necrosis factor (Ligand) superfamily, member 8 (Tumor necrosis factor ligand 3A) (cDNA, FLJ94189, Homo sapiens tumor necrosis factor (ligand) superfamily, member 8(TNFSF8), mRNA) |
| Synonyms | TNLG3A CD30L CD30LG hCG_29853 |
| Description | FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. |
| Accessions | P32971 A0A087X228 Q52M88 ENST00000618336.4 ENST00000223795.3 |
