CDK3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDK3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	897.19	21 / 21	19%	0.30	94 / 504
uterus	100%	1305.44	170 / 170	15%	0.21	69 / 459
ovary	100%	1242.18	180 / 180	13%	0.17	55 / 430
pancreas	100%	657.19	327 / 328	13%	0.19	23 / 178
lung	100%	1190.94	578 / 578	10%	0.14	121 / 1155
prostate	100%	2157.43	245 / 245	10%	0.13	51 / 502
kidney	100%	1179.52	89 / 89	5%	0.07	48 / 901
brain	98%	528.24	2578 / 2642	8%	0.10	53 / 705
thymus	100%	1733.98	653 / 653	5%	0.06	30 / 605
liver	100%	1334.37	226 / 226	5%	0.07	20 / 406
intestine	100%	987.61	966 / 966	5%	0.06	25 / 527
esophagus	100%	650.84	1442 / 1445	4%	0.05	7 / 183
breast	100%	1062.40	459 / 459	3%	0.04	32 / 1118
stomach	100%	733.29	359 / 359	2%	0.02	6 / 286
skin	100%	1022.65	1806 / 1809	2%	0.02	8 / 472
adrenal gland	100%	805.40	258 / 258	0%	0.00	1 / 230
adipose	100%	981.51	1204 / 1204	0%	0	0 / 0
spleen	100%	1745.40	241 / 241	0%	0	0 / 0
blood vessel	99%	533.35	1319 / 1335	0%	0	0 / 0
peripheral blood	94%	514.73	874 / 929	0%	0	0 / 0
heart	93%	402.58	805 / 861	0%	0	0 / 0
muscle	43%	112.62	348 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.07	2 / 29
tonsil	0%	0	0 / 0	7%	0.08	3 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0006974	Biological process	DNA damage response
GO_0010468	Biological process	regulation of gene expression
GO_0006468	Biological process	protein phosphorylation
GO_0051301	Biological process	cell division
GO_0008283	Biological process	cell population proliferation
GO_0045746	Biological process	negative regulation of Notch signaling pathway
GO_0010389	Biological process	regulation of G2/M transition of mitotic cell cycle
GO_0045023	Biological process	G0 to G1 transition
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0000307	Cellular component	cyclin-dependent protein kinase holoenzyme complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0030332	Molecular function	cyclin binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005515	Molecular function	protein binding
GO_0004693	Molecular function	cyclin-dependent protein serine/threonine kinase activity
GO_0005524	Molecular function	ATP binding

Gene name	CDK3
Protein name	Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) Cyclin dependent kinase 3
Synonyms	CDKN3
Description	FUNCTION: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. .
Accessions	ENST00000586261.2 ENST00000425876.6 ENST00000448471.3 K7EJ83 Q00526

CDK3 report