GUCA1A | OmnibusX

Name	Number of supported studies	Average coverage
eye	4 studies	52% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	75%	275.50	1990 / 2642	0%	0	0 / 705
bladder	5%	1.67	1 / 21	0%	0.02	2 / 504
prostate	4%	2.44	9 / 245	0%	0	0 / 502
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
stomach	3%	1.58	10 / 359	0%	0	0 / 286
esophagus	2%	0.98	24 / 1445	1%	0.01	1 / 183
intestine	2%	0.95	16 / 966	0%	0.00	1 / 527
eye	0%	0	0 / 0	1%	0.07	1 / 80
breast	1%	0.75	5 / 459	0%	0	0 / 1118
lung	1%	0.46	3 / 578	0%	0.00	1 / 1155
uterus	1%	0.51	1 / 170	0%	0	0 / 459
thymus	0%	0.33	3 / 653	0%	0	0 / 605
skin	0%	1.06	8 / 1809	0%	0	0 / 472
adrenal gland	0%	0	0 / 258	0%	0.03	1 / 230
muscle	0%	0.26	3 / 803	0%	0	0 / 0
heart	0%	0.10	2 / 861	0%	0	0 / 0
adipose	0%	0.10	2 / 1204	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0.01	1 / 901
blood vessel	0%	0.10	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
pancreas	0%	0	0 / 328	0%	0	0 / 178
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0007601	Biological process	visual perception
GO_0010753	Biological process	positive regulation of cGMP-mediated signaling
GO_0007602	Biological process	phototransduction
GO_0031284	Biological process	positive regulation of guanylate cyclase activity
GO_0071277	Biological process	cellular response to calcium ion
GO_0097381	Cellular component	photoreceptor disc membrane
GO_0001917	Cellular component	photoreceptor inner segment
GO_0120199	Cellular component	cone photoreceptor outer segment
GO_0030249	Molecular function	guanylate cyclase regulator activity
GO_0005509	Molecular function	calcium ion binding
GO_0008048	Molecular function	calcium sensitive guanylate cyclase activator activity
GO_0005515	Molecular function	protein binding

Gene name	GUCA1A
Protein name	Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A) Guanylyl cyclase-activating protein 1 (Guanylate cyclase activator 1A)
Synonyms	C6orf131 GCAP GUCA1 GCAP1
Description	FUNCTION: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated . This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). .
Accessions	A0A7I2V6E2 ENST00000679182.1 P43080 ENST00000372958.2

GUCA1A report