SCT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCT at tissue level.

III. Associated gene sets

GO_0021766Biological processhippocampus development
GO_0007165Biological processsignal transduction
GO_0048566Biological processembryonic digestive tract development
GO_0002024Biological processdiet induced thermogenesis
GO_0090187Biological processpositive regulation of pancreatic juice secretion
GO_0032098Biological processregulation of appetite
GO_0050996Biological processpositive regulation of lipid catabolic process
GO_0031667Biological processresponse to nutrient levels
GO_0048167Biological processregulation of synaptic plasticity
GO_0043950Biological processpositive regulation of cAMP-mediated signaling
GO_0030157Biological processpancreatic juice secretion
GO_1903640Biological processnegative regulation of gastrin-induced gastric acid secretion
GO_0007420Biological processbrain development
GO_0090274Biological processpositive regulation of somatostatin secretion
GO_0009992Biological processintracellular water homeostasis
GO_0005575Cellular componentcellular_component
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005179Molecular functionhormone activity
GO_0005102Molecular functionsignaling receptor binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0046659Molecular functiondigestive hormone activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCT
Protein nameSecretin
Synonyms
DescriptionFUNCTION: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis . Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells . Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). .

AccessionsP09683
ENST00000176195.4
ENST00000622382.2