PSG9 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PSG9 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PSG9 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0002461Biological processtolerance induction dependent upon immune response
GO_0002682Biological processregulation of immune system process
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0045589Biological processregulation of regulatory T cell differentiation
GO_0007565Biological processfemale pregnancy
GO_0002774Biological processFc receptor mediated inhibitory signaling pathway
GO_0070021Cellular componenttransforming growth factor beta ligand-receptor complex
GO_0009986Cellular componentcell surface
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_1990782Molecular functionprotein tyrosine kinase binding

IV. Literature review

[source]
Gene namePSG9
Protein namePregnancy specific beta-1-glycoprotein 9
Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7)
PSG9 protein
SynonymshCG_1995680
PSG11
DescriptionFUNCTION: Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 . The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells . Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset . Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells . May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 . .

AccessionsG3XAA7
Q05DN5
ENST00000244293.11 [Q00887-2]
M0R0E4
ENST00000593948.5
ENST00000621109.4
ENST00000596730.1
E7EW65
ENST00000291752.9
H7C1I4
Q00887
A0A087WYK1
ENST00000443718.7
ENST00000270077.8 [Q00887-1]
Q6LEU7
ENST00000418820.6
M0R0U8