ATF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_1903893Biological processpositive regulation of ATF6-mediated unfolded protein response
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0036500Biological processATF6-mediated unfolded protein response
GO_0001654Biological processeye development
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0006457Biological processprotein folding
GO_0010508Biological processpositive regulation of autophagy
GO_0043065Biological processpositive regulation of apoptotic process
GO_0036503Biological processERAD pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005635Cellular componentnuclear envelope
GO_0000139Cellular componentGolgi membrane
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATF6
Protein nameCyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
Activating transcription factor 6
Synonyms
DescriptionFUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane . Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) . .; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR . Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') . Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor . May play a role in foveal development and cone function in the retina . .

AccessionsENST00000681557.1
ENST00000681801.1
ENST00000367942.4
ENST00000679833.1
ENST00000679853.1
A0A7P0Z4I7
A0A7P0TAD1
ENST00000681912.1
ENST00000680481.1
ENST00000679886.1
A0A7P0T9V3
A0A7P0T9H5
A0A7P0TAI7
A0A7P0TAF2
A0A7P0Z421
ENST00000680688.1
A0A7P0T8R5
A0A7P0TAB8
A0A7P0T8Y1
ENST00000681001.1
ENST00000681036.1
ENST00000681541.1
ENST00000680633.1
A0A7P0T992
ENST00000681492.1
A0A7P0TB89
ENST00000681169.1
P18850
ENST00000680462.1
ENST00000681738.1
A0A7P0TAH1