Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 25 studies | 29% ± 11% | |
macrophage | 21 studies | 33% ± 19% | |
endothelial cell of lymphatic vessel | 15 studies | 28% ± 13% | |
microglial cell | 15 studies | 46% ± 16% | |
fibroblast | 13 studies | 24% ± 10% | |
oligodendrocyte | 12 studies | 30% ± 12% | |
glutamatergic neuron | 10 studies | 39% ± 26% | |
oligodendrocyte precursor cell | 10 studies | 28% ± 12% | |
myeloid cell | 10 studies | 30% ± 8% | |
astrocyte | 10 studies | 34% ± 17% | |
GABAergic neuron | 8 studies | 38% ± 22% | |
epithelial cell | 8 studies | 32% ± 18% | |
monocyte | 7 studies | 30% ± 8% | |
ciliated cell | 7 studies | 20% ± 5% | |
type I pneumocyte | 7 studies | 23% ± 5% | |
classical monocyte | 6 studies | 22% ± 5% | |
neuron | 6 studies | 32% ± 16% | |
interneuron | 6 studies | 39% ± 24% | |
adipocyte | 6 studies | 24% ± 4% | |
dendritic cell | 6 studies | 29% ± 5% | |
type II pneumocyte | 6 studies | 27% ± 5% | |
smooth muscle cell | 6 studies | 21% ± 3% | |
pericyte | 5 studies | 26% ± 13% | |
plasma cell | 5 studies | 28% ± 4% | |
mast cell | 5 studies | 25% ± 5% | |
lymphocyte | 5 studies | 23% ± 6% | |
club cell | 5 studies | 26% ± 5% | |
granule cell | 4 studies | 23% ± 5% | |
endothelial cell of artery | 4 studies | 19% ± 4% | |
vein endothelial cell | 4 studies | 27% ± 14% | |
capillary endothelial cell | 4 studies | 19% ± 4% | |
basal cell | 4 studies | 29% ± 14% | |
conventional dendritic cell | 3 studies | 21% ± 3% | |
hematopoietic precursor cell | 3 studies | 25% ± 5% | |
GABAergic interneuron | 3 studies | 22% ± 5% | |
glial cell | 3 studies | 18% ± 2% | |
amacrine cell | 3 studies | 21% ± 3% | |
retinal cone cell | 3 studies | 26% ± 3% | |
retinal pigment epithelial cell | 3 studies | 33% ± 17% | |
B cell | 3 studies | 22% ± 5% | |
mesothelial cell | 3 studies | 22% ± 5% | |
mononuclear phagocyte | 3 studies | 30% ± 8% | |
non-classical monocyte | 3 studies | 24% ± 5% | |
Mueller cell | 3 studies | 30% ± 12% | |
respiratory goblet cell | 3 studies | 25% ± 9% | |
hepatocyte | 3 studies | 64% ± 23% | |
abnormal cell | 3 studies | 27% ± 15% | |
neural progenitor cell | 3 studies | 20% ± 1% | |
T cell | 3 studies | 21% ± 1% | |
alveolar macrophage | 3 studies | 33% ± 10% | |
goblet cell | 3 studies | 41% ± 29% | |
transit amplifying cell | 3 studies | 30% ± 19% | |
renal principal cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2967.78 | 1445 / 1445 | 100% | 33.95 | 183 / 183 |
lung | 100% | 4346.74 | 578 / 578 | 100% | 36.74 | 1155 / 1155 |
ovary | 100% | 2820.49 | 180 / 180 | 100% | 28.61 | 430 / 430 |
pancreas | 100% | 3353.92 | 328 / 328 | 100% | 32.34 | 178 / 178 |
breast | 100% | 3628.42 | 459 / 459 | 100% | 54.18 | 1117 / 1118 |
intestine | 100% | 3269.45 | 966 / 966 | 100% | 28.70 | 526 / 527 |
bladder | 100% | 3419.76 | 21 / 21 | 100% | 31.26 | 503 / 504 |
stomach | 100% | 2705.26 | 359 / 359 | 100% | 31.82 | 285 / 286 |
uterus | 100% | 3430.96 | 170 / 170 | 100% | 30.71 | 457 / 459 |
liver | 100% | 2425.32 | 226 / 226 | 100% | 31.82 | 404 / 406 |
thymus | 100% | 3479.01 | 653 / 653 | 99% | 31.61 | 601 / 605 |
prostate | 100% | 3375.60 | 245 / 245 | 99% | 30.68 | 498 / 502 |
brain | 99% | 1899.13 | 2610 / 2642 | 100% | 31.22 | 705 / 705 |
skin | 100% | 4077.08 | 1808 / 1809 | 99% | 38.28 | 465 / 472 |
kidney | 100% | 2781.37 | 89 / 89 | 98% | 29.10 | 883 / 901 |
adrenal gland | 100% | 3041.27 | 258 / 258 | 94% | 24.60 | 216 / 230 |
adipose | 100% | 3705.03 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3884.51 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.74 | 29 / 29 |
spleen | 100% | 3129.60 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.72 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.14 | 1 / 1 |
muscle | 100% | 1956.46 | 801 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4969.73 | 918 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 1907.49 | 835 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 18.03 | 75 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007601 | Biological process | visual perception |
GO_1903893 | Biological process | positive regulation of ATF6-mediated unfolded protein response |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0007165 | Biological process | signal transduction |
GO_0036500 | Biological process | ATF6-mediated unfolded protein response |
GO_0001654 | Biological process | eye development |
GO_0030968 | Biological process | endoplasmic reticulum unfolded protein response |
GO_0006457 | Biological process | protein folding |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0036503 | Biological process | ERAD pathway |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005635 | Cellular component | nuclear envelope |
GO_0000139 | Cellular component | Golgi membrane |
GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ATF6 |
Protein name | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] Activating transcription factor 6 |
Synonyms | |
Description | FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane . Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) . .; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR . Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') . Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor . May play a role in foveal development and cone function in the retina . . |
Accessions | ENST00000681557.1 ENST00000681801.1 ENST00000367942.4 ENST00000679833.1 ENST00000679853.1 A0A7P0Z4I7 A0A7P0TAD1 ENST00000681912.1 ENST00000680481.1 ENST00000679886.1 A0A7P0T9V3 A0A7P0T9H5 A0A7P0TAI7 A0A7P0TAF2 A0A7P0Z421 ENST00000680688.1 A0A7P0T8R5 A0A7P0TAB8 A0A7P0T8Y1 ENST00000681001.1 ENST00000681036.1 ENST00000681541.1 ENST00000680633.1 A0A7P0T992 ENST00000681492.1 A0A7P0TB89 ENST00000681169.1 P18850 ENST00000680462.1 ENST00000681738.1 A0A7P0TAH1 |